| Gene Symbol |
UPP2
|
| Entrez Gene |
151531
|
| Alt Symbol |
UDRPASE2, UP2, UPASE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
uridine phosphorylase 2
|
| Other Description |
UPase 2|liver-specific uridine phosphorylase|urdPase 2|uridine phosphorylase-2
|
| Swissprots |
B3KV87 O95045
|
| Accessions |
AAD12227 EAX11437 O95045 AA995921 AK122743 BAG53699 AW771260 AY225131 AAO61681 BC033529 AAH33529 HG494776 HQ447870 ADQ32354 XM_005246359 XP_005246416 XR_922880 XR_922881 NM_001135098 NP_001128570 NM_173355 NP_775491
|
| Function |
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
|
| Tissue Specificity |
Predominantly expressed in kidney. {ECO:0000269|PubMed:12849978}.
|
| Top Pathways |
Drug metabolism - other enzymes, Pyrimidine metabolism
|
![Western Blot: UPP2 Overexpression Lysate (Adult Normal) [NBL1-17626] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UPP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6866_UPP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17626-img0002.jpg)