Gene Symbol | UPP2 |
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Entrez Gene | 151531 |
Alt Symbol | UDRPASE2, UP2, UPASE2 |
Species | Human |
Gene Type | protein-coding |
Description | uridine phosphorylase 2 |
Other Description | UPase 2|liver-specific uridine phosphorylase|urdPase 2|uridine phosphorylase-2 |
Swissprots | B3KV87 O95045 |
Accessions | AAD12227 EAX11437 O95045 AA995921 AK122743 BAG53699 AW771260 AY225131 AAO61681 BC033529 AAH33529 HG494776 HQ447870 ADQ32354 XM_005246359 XP_005246416 XR_922880 XR_922881 NM_001135098 NP_001128570 NM_173355 NP_775491 |
Function | Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. |
Tissue Specificity | Predominantly expressed in kidney. {ECO:0000269|PubMed:12849978}. |
Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism |
UPase 2 CRISPR/Cas9 KO Plasmid (h) - sc-414705 from Santa Cruz Biotechnology
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UPase 2 HDR Plasmid (h) - sc-414705-HDR from Santa Cruz Biotechnology
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UPase 2 Double Nickase Plasmid (h) - sc-414705-NIC from Santa Cruz Biotechnology
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UPase 2 Double Nickase Plasmid (h2) - sc-414705-NIC-2 from Santa Cruz Biotechnology
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UPase 2 CRISPR Activation Plasmid (h) - sc-414705-ACT from Santa Cruz Biotechnology
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UPase 2 CRISPR Activation Plasmid (h2) - sc-414705-ACT-2 from Santa Cruz Biotechnology
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UPase 2 Lentiviral Activation Particles (h) - sc-414705-LAC from Santa Cruz Biotechnology
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UPase 2 Lentiviral Activation Particles (h2) - sc-414705-LAC-2 from Santa Cruz Biotechnology
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UPase 2 siRNA (h) - sc-106674 from Santa Cruz Biotechnology
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UPase 2 shRNA Plasmid (h) - sc-106674-SH from Santa Cruz Biotechnology
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UPase 2 shRNA (h) Lentiviral Particles - sc-106674-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU144061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22527 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22527 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07777 from Sigma-Aldrich
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UPP2 siRNA (Human) - CRJ5703 from Cohesion Biosciences
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UPP2 - MBS8205426 from MyBioSource
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shRNA set against Human UPP2 (NM_173355.3) - SHH440856 from Creative biogene
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UPP2 shRNA Plasmid (Human) - CHJ5703 from Cohesion Biosciences
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UPP2 miRNA 3'UTR clone - MiUTR3H-16510 from Creative biogene
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UPP2 miRNA 3'UTR clone - MiUTR3H-16511 from Creative biogene
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