UNC13B
| Gene Symbol | UNC13B |
|---|---|
| Entrez Gene | 10497 |
| Alt Symbol | MUNC13, UNC13, Unc13h2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | unc-13 homolog B (C. elegans) |
| Other Description | homolog of rat Munc13 (diacylglycerol-binding)|munc13-2|protein unc-13 homolog B |
| Swissprots | Q5VYM8 O14795 Q2NKJ5 |
| Accessions | EAW58383 EAW58384 O14795 AB209998 BAE06080 AF020202 AAC19406 AK296836 BAG59406 BC111781 AAI11782 BC111800 AAI11801 BP236693 EF139849 XM_011517681 XP_011515983 XM_011517682 XP_011515984 XM_011517683 XP_011515985 XM_011517684 XP_011515986 XM_011517685 XP_011515987 XM_011517686 XP_011515988 NM_006377 NP_006368 |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in kidney cortical epithelial cells and brain. {ECO:0000269|PubMed:9607201}. |
| Top Pathways | Synaptic vesicle cycle |
Munc13-1/2 (T-20) - sc-13630 from Santa Cruz Biotechnology
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Munc13-2 (E-14) - sc-13634 from Santa Cruz Biotechnology
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Munc13-2 (R-18) - sc-13635 from Santa Cruz Biotechnology
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Anti-UNC13B antibody - ab175868 from Abcam
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Anti-UNC13B antibody - ab97924 from Abcam
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Anti-UNC13B antibody - ab97664 from Abcam
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Anti-UNC13B antibody - N-terminal - ab171615 from Abcam
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Anti-UNC13B Antibody (aa418-1591) - LS-C124030 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal) - LS-C154789 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, APC) - LS-C273041 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, FITC) - LS-C273042 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, AP) - LS-C273040 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, Biotin) - LS-C273043 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, Azide-free, HRP) - LS-C273044 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, AP) - LS-C279140 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, APC) - LS-C279141 from LifeSpan Bioscience
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Anti-UNC13B Antibody (aa262-292, PE) - LS-C273045 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, FITC) - LS-C279142 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, Biotin) - LS-C279143 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, AP) - LS-C279145 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, Azide-free, HRP) - LS-C279144 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, PE) - LS-C279147 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, APC) - LS-C279146 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, Biotin) - LS-C279148 from LifeSpan Bioscience
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Anti-UNC13B Antibody (Internal, FITC) - LS-C279149 from LifeSpan Bioscience
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