UNC13B

Gene Symbol	UNC13B
Entrez Gene	10497
Alt Symbol	MUNC13, UNC13, Unc13h2
Species	Human
Gene Type	protein-coding
Description	unc-13 homolog B (C. elegans)
Other Description	homolog of rat Munc13 (diacylglycerol-binding)|munc13-2|protein unc-13 homolog B
Swissprots	Q5VYM8 O14795 Q2NKJ5
Accessions	EAW58383 EAW58384 O14795 AB209998 BAE06080 AF020202 AAC19406 AK296836 BAG59406 BC111781 AAI11782 BC111800 AAI11801 BP236693 EF139849 XM_011517681 XP_011515983 XM_011517682 XP_011515984 XM_011517683 XP_011515985 XM_011517684 XP_011515986 XM_011517685 XP_011515987 XM_011517686 XP_011515988 NM_006377 NP_006368
Function	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in kidney cortical epithelial cells and brain. {ECO:0000269|PubMed:9607201}.
Top Pathways	Synaptic vesicle cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Munc 13 peptide - ab45487 from Abcam Category Peptide Species Human

Human UNC13B protein fragment - ab161024 from Abcam Category Protein Source Wheat germ Species Human

UNC13B Antibody Blocking Peptide - LS-E2197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UNC13B Antibody Blocking Peptide - LS-E27472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UNC13B Antibody Blocking Peptide - LS-E9844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UNC13B Protein - H00010497-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UNC13B-Antibody-N-term-Blocking-Peptide - BP13116a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UNC13B-Antibody-Center-Blocking-Peptide - BP8905c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UNC13B blocking peptide - GTX89723-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Goat anti Unc13b antibody Immunizing peptide - orb66195 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

UNC13B - H00010497-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UNC13B - H00010497-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UNC13B fusion protein - Ag16478 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

UNC13B fusion protein - ag17450 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human UNC13B, GST-tagged - UNC13B-3596H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein unc-13 homolog B(UNC13B) ,partial - CSB-YP025622HU CSB-EP025622HU CSB-BP025622HU CSB-MP025622HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UNC13B Recombinant Protein Antigen - NBP1-83244PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UNC13B Recombinant Protein Antigen - NBP2-49364PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

UNC13B Peptide, Human - M34GP17085H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein unc-13 homolog B (UNC13B), partial, Recombinant Protein - MBS1000612 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more