| Gene Symbol | UNC13B |
|---|---|
| Entrez Gene | 10497 |
| Alt Symbol | MUNC13, UNC13, Unc13h2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | unc-13 homolog B (C. elegans) |
| Other Description | homolog of rat Munc13 (diacylglycerol-binding)|munc13-2|protein unc-13 homolog B |
| Swissprots | Q5VYM8 O14795 Q2NKJ5 |
| Accessions | EAW58383 EAW58384 O14795 AB209998 BAE06080 AF020202 AAC19406 AK296836 BAG59406 BC111781 AAI11782 BC111800 AAI11801 BP236693 EF139849 XM_011517681 XP_011515983 XM_011517682 XP_011515984 XM_011517683 XP_011515985 XM_011517684 XP_011515986 XM_011517685 XP_011515987 XM_011517686 XP_011515988 NM_006377 NP_006368 |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in kidney cortical epithelial cells and brain. {ECO:0000269|PubMed:9607201}. |
| Top Pathways | Synaptic vesicle cycle |
Munc13-2 CRISPR/Cas9 KO Plasmid (h) - sc-406067 from Santa Cruz Biotechnology
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Munc13-2 HDR Plasmid (h) - sc-406067-HDR from Santa Cruz Biotechnology
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Munc13-2 Double Nickase Plasmid (h) - sc-406067-NIC from Santa Cruz Biotechnology
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Munc13-2 Double Nickase Plasmid (h2) - sc-406067-NIC-2 from Santa Cruz Biotechnology
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Munc13-2 CRISPR Activation Plasmid (h) - sc-406067-ACT from Santa Cruz Biotechnology
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Munc13-2 CRISPR Activation Plasmid (h2) - sc-406067-ACT-2 from Santa Cruz Biotechnology
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Munc13-2 Lentiviral Activation Particles (h) - sc-406067-LAC from Santa Cruz Biotechnology
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Munc13-2 Lentiviral Activation Particles (h2) - sc-406067-LAC-2 from Santa Cruz Biotechnology
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Munc13-2 siRNA (h) - sc-42022 from Santa Cruz Biotechnology
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Munc13-2 shRNA Plasmid (h) - sc-42022-SH from Santa Cruz Biotechnology
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Munc13-2 shRNA (h) Lentiviral Particles - sc-42022-V from Santa Cruz Biotechnology
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UNC13B RNAi - H00010497-R02 from Novus Biologicals
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MISSION® esiRNA - EHU100941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22494 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22494 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08688 from Sigma-Aldrich
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UNC13B siRNA (Human) - CRH7133 from Cohesion Biosciences
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UNC13B - MBS8226414 from MyBioSource
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shRNA set against Human UNC13B (NM_006377.3) - SHH440490 from Creative biogene
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shRNA set against Human UNC13B(NM_006377.3) - SHL114588 from Creative biogene
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Human UNC13B siRNA - orb267635 from Biorbyt
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UNC13B shRNA Plasmid (Human) - CHH7133 from Cohesion Biosciences
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UNC13B miRNA 3'UTR clone - MiUTR1H-11009 from Creative biogene
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