| Gene Symbol |
UNC13B
|
| Entrez Gene |
10497
|
| Alt Symbol |
MUNC13, UNC13, Unc13h2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-13 homolog B (C. elegans)
|
| Other Description |
homolog of rat Munc13 (diacylglycerol-binding)|munc13-2|protein unc-13 homolog B
|
| Swissprots |
Q5VYM8 O14795 Q2NKJ5
|
| Accessions |
EAW58383 EAW58384 O14795 AB209998 BAE06080 AF020202 AAC19406 AK296836 BAG59406 BC111781 AAI11782 BC111800 AAI11801 BP236693 EF139849 XM_011517681 XP_011515983 XM_011517682 XP_011515984 XM_011517683 XP_011515985 XM_011517684 XP_011515986 XM_011517685 XP_011515987 XM_011517686 XP_011515988 NM_006377 NP_006368
|
| Function |
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney cortical epithelial cells and brain. {ECO:0000269|PubMed:9607201}.
|
| Top Pathways |
Synaptic vesicle cycle
|