| Gene Symbol |
MCU
|
| Entrez Gene |
90550
|
| Alt Symbol |
C10orf42, CCDC109A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial calcium uniporter
|
| Other Description |
calcium uniporter protein, mitochondrial|coiled-coil domain-containing protein 109A
|
| Swissprots |
B2RDF3 Q8NE86 Q96FL3 B3KXV7
|
| Accessions |
EAW54460 EAW54461 EAW54462 Q8NE86 AK025699 AK075439 AK128016 BAG54619 AK301475 BAG62992 AK310455 AK311133 AK315519 BAG37900 BC010682 AAH10682 BC034235 AAH34235 HY146050 JF432665 ADZ15882 NM_001270679 NP_001257608 NM_001270680 NP_001257609 NM_138357 NP_612366 NR_073062
|
| Function |
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}.
|
![Western Blot: CCDC109A Overexpression Lysate (Adult Normal) [NBP2-05662] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCDC109A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10515_CCDC109A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05662-img0001.jpg)