MCU

Gene Symbol MCU
Entrez Gene 90550
Alt Symbol C10orf42, CCDC109A
Species Human
Gene Type protein-coding
Description mitochondrial calcium uniporter
Other Description calcium uniporter protein, mitochondrial|coiled-coil domain-containing protein 109A
Swissprots B2RDF3 Q8NE86 Q96FL3 B3KXV7
Accessions EAW54460 EAW54461 EAW54462 Q8NE86 AK025699 AK075439 AK128016 BAG54619 AK301475 BAG62992 AK310455 AK311133 AK315519 BAG37900 BC010682 AAH10682 BC034235 AAH34235 HY146050 JF432665 ADZ15882 NM_001270679 NP_001257608 NM_001270680 NP_001257609 NM_138357 NP_612366 NR_073062
Function Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}.

Human MCU full length protein - ab164833 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164833 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human CCDC109A Protein - H00090550-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CCDC109A - H00090550-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CCDC109A - H00090550-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CCDC109A fusion protein - Ag24733 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

CCDC109A fusion protein - Ag24741 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET30a
Species Human

CCDC109A - TP306952 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CCDC109A

CCDC109A Recombinant Protein Antigen - NBP1-88534PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

MCU Peptide, Human - M34GP09331H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

MCU peptide - orb374971 from Biorbyt

Category Peptide
Prices $170.00
Sizes 1 mg

CCDC109A Recombinant Protein Antigen - NBP2-59029PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Calcium uniporter protein (MCU), Recombinant Protein - MBS7020052 from MyBioSource

Category Protein
Prices $1,160.00, $2,145.00, $3,355.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human

MCU peptide - orb374970 from Biorbyt

Category Peptide

MCU peptide - orb374933 from Biorbyt

Category Peptide
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