MCU

Gene Symbol MCU
Entrez Gene 90550
Alt Symbol C10orf42, CCDC109A
Species Human
Gene Type protein-coding
Description mitochondrial calcium uniporter
Other Description calcium uniporter protein, mitochondrial|coiled-coil domain-containing protein 109A
Swissprots B2RDF3 Q8NE86 Q96FL3 B3KXV7
Accessions EAW54460 EAW54461 EAW54462 Q8NE86 AK025699 AK075439 AK128016 BAG54619 AK301475 BAG62992 AK310455 AK311133 AK315519 BAG37900 BC010682 AAH10682 BC034235 AAH34235 HY146050 JF432665 ADZ15882 NM_001270679 NP_001257608 NM_001270680 NP_001257609 NM_138357 NP_612366 NR_073062
Function Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}.

CCDC109A (E-16) - sc-246072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CCDC109A (E-16): sc-246072. Western blot analysis of CCDC109A expression in A549 whole cell lysate.

CCDC109A (Q-14) - sc-246071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MCU antibody - ab121499 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human duodenum labeling MCU in glandular cells with ab121499 at 1/50 dilution. Heat mediated antigen retrieval with citrate buffer pH 6 was performed.

CCDC109A Antibody - NBP1-88534 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CCDC109A Antibody [NBP1-88534] - Analysis in human cell line A-549.

Anti-MCU antibody produced in rabbit - HPA016480 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CCDC109A: <B>Cat. No. HPA016480</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-CCDC109A antibody (N-term) - STJ92067 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

Anti-MCU polyclonal antibody - DPAB8888 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MCU (aa 47-152) polyclonal antibody - DPABH-18251 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-MCU monoclonal antibody - DCABH-200933 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

MCU (D2Z3B) Rabbit mAb - 14997 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2Z3B
Western blot analysis of extracts from various cell lines using MCU (D2Z3B) Rabbit mAb.

MCU Antibody - CSB-PA070214 from Cusabio

Host Rabbit

CCDC109A antibody - 26312-1-AP from Proteintech Group

Prices $279.00
Sizes con: 52 μg/150μl
Host Rabbit
Clonality Polyclonal
HeLa cells were subjected to SDS PAGE followed by western blot with 26312-1-AP( CCDC109A Antibody) at dilution of 1:2000

MCU antibody (FITC) - orb318166 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

MCU antibody (FITC) - orb360885 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

CCDC109A Polyclonal Antibody - E20-70702 from Enogene

Prices $225.00
Sizes 100 µg
Clonality Polyclonal

CCDC109A Antibody - 45898 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis CCDC109A using HepG2 whole cell lysates

CCDC109A Antibody - DF9403 from Affinity Biosciences

Prices $220.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MCU Antibody,Biotin conjugated - CSB-PA847694LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MCU Antibody,FITC conjugated - CSB-PA847694LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MCU Antibody,HRP conjugated - CSB-PA847694LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

MCU Antibody - CSB-PA847694LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

CCDC109A Antibody - NBP2-59029 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

CCDC109A, Polyclonal Antibody - MBS8521683 from MyBioSource

Prices $290.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MCU / CCDC109A Antibody (Internal) - LS-C382483 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

MCU antibody - orb401356 from Biorbyt

Host Rabbit
Clonality Polyclonal
Western blot analysis of HL-60 whole cell lysate(Lane 1), HepG2 whole cell lysate(Lane 2), A549 whole cell lysate(Lane 3) using MCU antibody
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