MCU

Gene Symbol MCU
Entrez Gene 90550
Alt Symbol C10orf42, CCDC109A
Species Human
Gene Type protein-coding
Description mitochondrial calcium uniporter
Other Description calcium uniporter protein, mitochondrial|coiled-coil domain-containing protein 109A
Swissprots B2RDF3 Q8NE86 Q96FL3 B3KXV7
Accessions EAW54460 EAW54461 EAW54462 Q8NE86 AK025699 AK075439 AK128016 BAG54619 AK301475 BAG62992 AK310455 AK311133 AK315519 BAG37900 BC010682 AAH10682 BC034235 AAH34235 HY146050 JF432665 ADZ15882 NM_001270679 NP_001257608 NM_001270680 NP_001257609 NM_138357 NP_612366 NR_073062
Function Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:22822213, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:21685886, ECO:0000269|PubMed:21685888, ECO:0000269|PubMed:24231807}.

CCDC109A CRISPR/Cas9 KO Plasmid (h) - sc-413850 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A HDR Plasmid (h) - sc-413850-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A Double Nickase Plasmid (h) - sc-413850-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A Double Nickase Plasmid (h2) - sc-413850-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A CRISPR Activation Plasmid (h) - sc-413850-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A CRISPR Activation Plasmid (h2) - sc-413850-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A Lentiviral Activation Particles (h) - sc-413850-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A Lentiviral Activation Particles (h2) - sc-413850-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC109A siRNA (h) - sc-90666 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC109A shRNA Plasmid (h) - sc-90666-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC109A shRNA (h) Lentiviral Particles - sc-90666-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU157641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5453 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5453 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10523 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10523

MCU siRNA (Human) - CRJ3960 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Mcu (NM_138357.2) - SHH339551 from Creative biogene

Category siRNA
Species Reactivities Human

Human MCU siRNA - orb274461 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MCU shRNA Plasmid (Human) - CHJ3960 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MCU miRNA 3'UTR clone - MiUTR3H-13170 from Creative biogene

Species Reactivities Human
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