MYSM1

Gene Symbol MYSM1
Entrez Gene 114803
Alt Symbol 2A-DUB, 2ADUB
Species Human
Gene Type protein-coding
Description Myb-like, SWIRM and MPN domains 1
Other Description histone H2A deubiquitinase MYSM1|myb-like, SWIRM and MPN domain-containing protein 1
Swissprots Q7Z3G8 Q6AI53 B3KX65 Q96PX3 Q5VVJ2 Q68DD3 A8KA54
Accessions Q5VVJ2 AB067502 BAB67808 AK126835 BAG54377 AK292919 BAF85608 BC037536 BC167849 AAI67849 BX537912 CAD97896 BX648168 CR627323 CAH10370 CR749450 CAH18287 XM_006710314 XP_006710377 XM_011540573 XP_011538875 XM_011540574 XP_011538876 XR_246231 XR_946533 NM_001085487 NP_001078956
Function Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269|PubMed:17707232}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:17707232}.

MYSM1 (K-13) - sc-161894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MYSM1 (K-13): sc-161894. Western blot analysis of MYSM1 expression in rat brain tissue extract.

MYSM1 (P-14) - sc-161895 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MYSM1 (P-14): sc-161895. Western blot analysis of MYSM1 expression in KNRK nuclear extract (A) and rat brain tissue extract (B).

Anti-MYSM1 antibody - ab180570 from Abcam

Prices $357.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MYSM1 antibody (ab180570) at 1/500 dilution + MDA-MB-231 cell extract

Anti-MYSM1 antibody - ab107542 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MYSM1 antibody (ab107542) at 1/100 dilution + MDA-MB231 cell lysate at 35 µg

Anti-MYSM1 antibody - ab110109 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of MYSM1 in Immunoprecipitates of Jurkat whole cell lysate (1 mg for IP, 20% of IP loaded) using ab110109 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-MYSM1 antibody which recognizes an upstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-MYSM1 antibody - C-terminal - ab139570 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MYSM1 antibody - C-terminal (ab139570) at 1 µg/ml + Human fetal liver lysate at 10 µg

Anti-MYSM1 Antibody - LS-C190117 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa111-139, AP) - LS-C237881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa111-139, APC) - LS-C237882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa111-139, Biotin) - LS-C237883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa111-139, FITC) - LS-C237884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa111-139, PE) - LS-C237885 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa520-569) - LS-C199298 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma, using MYSM1 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-MYSM1 Antibody (aa111-139, Azide-free, HRP) - LS-C248875 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa150-200) - LS-C289719 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa700-750) - LS-C289720 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody - LS-C341543 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa118-147) - LS-C323213 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (aa145-194) - LS-C169899 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody (C-Terminus) - LS-C169898 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MYSM1 Antibody - LS-C343768 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of GFP-MYSM1 transfected cell lysate (20ug) at ~122kDa by PAb to MYSM1 at 1:1000 dilution. Other bands seen are degradation products of the full-length protein and are abolished upon peptide blockade.

Anti-MYSM1 Antibody - LS-C332363 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney cancer tissue using MYSM1 antibody at dilution of 1:200 (x400 lens).

Anti-MYSM1 Antibody (aa111-139) - LS-C164729 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MYSM1 Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The MYSM1 antibody detected the MYSM1 protein (arrow).

MYSM1 Antibody - NBP2-33709 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MYSM1 Antibody [NBP2-33709] - Immunohistochemical staining of human bone marrow shows strong nuclear positivity in hematopoietic cells.

MYSM1 Antibody - NBP1-52626 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MYSM1 Antibody [NBP1-52626] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-MYSM1 antibody used for IP at 6 mcg/mg lysate. MYSM1 was less efficiently immunoprecipitated by rabbit anti-MYSM1 antibody NBP1-52625, which recognizes an upstream epitope.
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