Gene Symbol | MYSM1 |
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Entrez Gene | 114803 |
Alt Symbol | 2A-DUB, 2ADUB |
Species | Human |
Gene Type | protein-coding |
Description | Myb-like, SWIRM and MPN domains 1 |
Other Description | histone H2A deubiquitinase MYSM1|myb-like, SWIRM and MPN domain-containing protein 1 |
Swissprots | Q7Z3G8 Q6AI53 B3KX65 Q96PX3 Q5VVJ2 Q68DD3 A8KA54 |
Accessions | Q5VVJ2 AB067502 BAB67808 AK126835 BAG54377 AK292919 BAF85608 BC037536 BC167849 AAI67849 BX537912 CAD97896 BX648168 CR627323 CAH10370 CR749450 CAH18287 XM_006710314 XP_006710377 XM_011540573 XP_011538875 XM_011540574 XP_011538876 XR_246231 XR_946533 NM_001085487 NP_001078956 |
Function | Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269|PubMed:17707232}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:17707232}. |
MYSM1 Antibody Blocking Peptide - LS-E279 from LifeSpan Bioscience
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MYSM1 Antibody Blocking Peptide - LS-E24340 from LifeSpan Bioscience
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MYSM1 Antibody Blocking Peptide - LS-E24341 from LifeSpan Bioscience
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MYSM1-Antibody-N-term-Blocking-Peptide - BP10517a from Abgent, a WuXi AppTec company
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MYSM1 - H00114803-P01-10 from Acris Antibodies
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MYSM1 - H00114803-P01-25 from Acris Antibodies
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Recombinant Human MYSM1 - MYSM1-1125H from Creative Biomart
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Recombinant Human Histone H2A deubiquitinase MYSM1(MYSM1) ,partial - CSB-YP716576HU CSB-EP716576HU CSB-BP716576HU CSB-MP716576HU from Cusabio
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MYSM1 Peptide - abx165039 from Abbexa
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MYSM1 - TP320811 from Acris Antibodies
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Recombinant Human MYSM1 Protein, CF - E-598 from R&D Systems
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MYSM1 Recombinant Protein Antigen - NBP2-33709PEP from Novus Biologicals
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MYSM1 Peptide, Human - M34GP10056H from Creative Peptides
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MYSM1 - E-598 from Boston Biochem
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Histone H2A deubiquitinase MYSM1 (MYSM1), partial, Recombinant Protein - MBS1383399 from MyBioSource
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Recombinant Human MYSM1 Protein, CF - E-598 from Novus Biologicals
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MYSM1 peptide - orb73002 from Biorbyt
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