| Gene Symbol |
MYSM1
|
| Entrez Gene |
114803
|
| Alt Symbol |
2A-DUB, 2ADUB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Myb-like, SWIRM and MPN domains 1
|
| Other Description |
histone H2A deubiquitinase MYSM1|myb-like, SWIRM and MPN domain-containing protein 1
|
| Swissprots |
Q7Z3G8 Q6AI53 B3KX65 Q96PX3 Q5VVJ2 Q68DD3 A8KA54
|
| Accessions |
Q5VVJ2 AB067502 BAB67808 AK126835 BAG54377 AK292919 BAF85608 BC037536 BC167849 AAI67849 BX537912 CAD97896 BX648168 CR627323 CAH10370 CR749450 CAH18287 XM_006710314 XP_006710377 XM_011540573 XP_011538875 XM_011540574 XP_011538876 XR_246231 XR_946533 NM_001085487 NP_001078956
|
| Function |
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269|PubMed:17707232}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:17707232}.
|