ANO6

Gene Symbol ANO6
Entrez Gene 196527
Alt Symbol BDPLT7, SCTS, TMEM16F
Species Human
Gene Type protein-coding
Description anoctamin 6
Other Description SCAN channel|anoctamin-6|small-conductance calcium-activated nonselective cation channel|transmembrane protein 16F
Swissprots Q4KMQ2 E9PB30 E7ENK4 A6NNM6 E9PCT2 Q8N3Q2 B9EGG0
Accessions Q4KMQ2 AA332109 AK095979 AK126409 BAG54324 AK302819 BAG64017 AK303996 BAG64913 AK310641 AL832340 AL833405 CAD38638 BC042383 BC063576 BC073891 BC098410 AAH98410 BC136445 AAI36446 XM_005268706 XP_005268763 XM_005268707 XP_005268764 XM_011538024 XP_011536326 NM_001025356 NP_001020527 NM_001142678 NP_001136150 NM_001142679 NP_001136151 NM_001204803 NP_001191732 NM_001142680
Function Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. {ECO:0000250|UniProtKB:Q6P9J9, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:21908539, ECO:0000269|PubMed:22006324, ECO:0000269|PubMed:22946059}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}. Note=Shows an intracellular localization according to PubMed:22075693.
Tissue Specificity Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. {ECO:0000269|PubMed:15067359}.

TMEM16F (G-14) - sc-136930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TMEM16F (G-14): sc-136930. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing cytoplasmic staining of ovarian stroma cells.

TMEM16F (T-13) - sc-136932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-ANO6 antibody - ab101909 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 antibody - N-terminal - ab156409 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab156409 stained PANC-1 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum/ 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab156409 at 1 µg/mL overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ANO6 Antibody (aa68-96, AP) - LS-C232691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96, Biotin) - LS-C232693 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96, FITC) - LS-C232695 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96, APC) - LS-C232694 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96, PE) - LS-C232697 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96, Azide-free, HRP) - LS-C249430 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa68-96) - LS-C319491 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ANO6 Antibody (aa791-840) - LS-C110983 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ANO6 antibody LS-C110983 Western blot of OVCAR-3 cell lysate.

Anti-ANO6 Antibody (aa480-529) - LS-C135165 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ANO6 antibody LS-C135165 Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml.

Anti-ANO6 Antibody (aa68-96) - LS-C157549 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ANO6 Antibody western blot of SW480 cell line lysates (35 ug/lane). The ANO6 antibody detected the ANO6 protein (arrow).

ANO6 Antibody - NBP1-59655 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ANO6 Antibody [NBP1-59655] - OVCAR-3 cell lysate, concentration 0.2-1 ug/ml.

ANO6 Antibody - NBP1-84207 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: ANO6 Antibody [NBP1-84207] - Staining of human pancreas shows strong cytoplasmic and membranous positivity in exocrine glandular cells.

Anti-ANO6 antibody produced in rabbit - HPA038958 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ANO6: <B>Cat. No. HPA038958</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic and membranous positivity in exocrine glandular cells.

Anti-ANO6 antibody produced in rabbit - SAB2105608 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ANO6: <B>Cat. No. SAB2105608</B>: TMEM16F in OVCAR-3 cell lysates with TMEM16F antibody at 1.0 μg/mL.

ANO6 antibody -C-terminal region (ARP44761_P050) - ARP44761_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANO6-Antibody-N-term - AP20252a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ANO6 Antibody (N-term) (Cat. #AP20252a) western blot analysis in SW480 cell line lysates (35ug/lane).This demonstrates the ANO6 antibody detected the ANO6 protein (arrow).

ANO6 antibody, C-term - GTX46636 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-ANO6 antibody, C-term used in Western blot. GTX46636

ANO6 antibody, Internal - GTX44687 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-ANO6 antibody, Internal used in Western blot. GTX44687

Anti -ANO6, NT (ANO6, TMEM16F, Anoctamin-6, Transmembrane protein 16F) - 031913 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -ANO6, NT (ANO6, TMEM16F, Anoctamin-6, Transmembrane protein 16F) (AP) - 031913-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -ANO6, NT (ANO6, TMEM16F, Anoctamin-6, Transmembrane protein 16F) (APC) - 031913-APC from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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