SIGLEC10
| Gene Symbol | SIGLEC10 |
|---|---|
| Entrez Gene | 89790 |
| Alt Symbol | PRO940, SIGLEC-10, SLG2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sialic acid binding Ig-like lectin 10 |
| Other Description | sialic acid binding Ig-like lectin 10 Ig-like lectin 7|sialic acid-binding Ig-like lectin 10|siglec-like gene 2|siglec-like protein 2 |
| Swissprots | A8K1I5 F8W917 C9JM10 Q96LC7 Q96G54 Q6UXI8 Q3MIR5 Q96LC8 C9JJ33 A8K3C7 |
| Accessions | AAK40255 AAK40256 EAW72012 EAW72013 EAW72014 EAW72015 EAW72016 Q96LC7 AF301007 AAM83254 AF310233 AAK55139 AF311905 AAK92542 AK122619 BAC85493 AK289900 BAF82589 AK290542 BAF83231 AK292025 BAF84714 AK294185 BAH11692 AK303514 BAH13979 AK303717 BAH14029 AK308982 AY032685 AAK51124 AY358337 AAQ88703 BC009955 AAH09955 BC101725 AAI01726 BC143497 AAI43498 BC143500 AAI43501 XM_005259366 XP_005259423 XM_005259367 XP_005259424 XM_005259369 XP_005259426 XM_011527439 XP_011525741 NM_001171160 NM_001171156 NP_001164627 NM_001171157 NP_001164628 NM_001171158 NP_001164629 NM_001171159 NP_001164630 NM_001171161 NP_001164632 NM_033130 NP_149121 |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. |
| Subcellular Location | Isoform 5: Secreted. |
| Tissue Specificity | Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells. |
Siglec-10 CRISPR/Cas9 KO Plasmid (h) - sc-417871 from Santa Cruz Biotechnology
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Siglec-10 HDR Plasmid (h) - sc-417871-HDR from Santa Cruz Biotechnology
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Siglec-10 Double Nickase Plasmid (h) - sc-417871-NIC from Santa Cruz Biotechnology
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Siglec-10 Double Nickase Plasmid (h2) - sc-417871-NIC-2 from Santa Cruz Biotechnology
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Siglec-10 CRISPR Activation Plasmid (h) - sc-417871-ACT from Santa Cruz Biotechnology
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Siglec-10 CRISPR Activation Plasmid (h2) - sc-417871-ACT-2 from Santa Cruz Biotechnology
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Siglec-10 Lentiviral Activation Particles (h) - sc-417871-LAC from Santa Cruz Biotechnology
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Siglec-10 Lentiviral Activation Particles (h2) - sc-417871-LAC-2 from Santa Cruz Biotechnology
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Siglec-10 siRNA (h) - sc-97663 from Santa Cruz Biotechnology
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Siglec-10 shRNA Plasmid (h) - sc-97663-SH from Santa Cruz Biotechnology
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Siglec-10 shRNA (h) Lentiviral Particles - sc-97663-V from Santa Cruz Biotechnology
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Siglec-10 RNAi - H00089790-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19327 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19327 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07715 from Sigma-Aldrich
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SIGLEC10 siRNA (Human) - CRJ3856 from Cohesion Biosciences
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SIGLEC10 - MBS8217360 from MyBioSource
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shRNA set against Human SIGLEC10 (NM_033130.4) - SHH407432 from Creative biogene
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Human SIGLEC10 siRNA - orb274357 from Biorbyt
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SIGLEC10 shRNA Plasmid (Human) - CHJ3856 from Cohesion Biosciences
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SIGLEC10 miRNA 3'UTR clone - MiUTR3H-08206 from Creative biogene
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