| Gene Symbol |
GALNT4
|
| Entrez Gene |
8693
|
| Alt Symbol |
GALNAC-T4, GALNACT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polypeptide N-acetylgalactosaminyltransferase 4
|
| Other Description |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)|polypeptide GalNAc transferase 4|pp-GaNTase 4|protein-UDP acetylgalactosaminyltransferase 4
|
| Swissprots |
O00208 Q8N4A0 B4DMX6 B2R775
|
| Accessions |
CAA69875 EAW97428 Q8N4A0 AK026150 AK026438 AK312870 BAG35722 AW835269 BC036390 AAH36390 CR739813 DA109687 DQ891684 ABM82610 DQ894869 ABM85795 DQ896831 ABM87830 EU176606 ABW03407 NM_003774 NP_003765
|
| Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305|PubMed:9804815}; Single-pass type II membrane protein {ECO:0000305|PubMed:9804815}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in mucous cells. {ECO:0000269|PubMed:9804815}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|