Gene Symbol | GALNT4 |
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Entrez Gene | 8693 |
Alt Symbol | GALNAC-T4, GALNACT4 |
Species | Human |
Gene Type | protein-coding |
Description | polypeptide N-acetylgalactosaminyltransferase 4 |
Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)|polypeptide GalNAc transferase 4|pp-GaNTase 4|protein-UDP acetylgalactosaminyltransferase 4 |
Swissprots | O00208 Q8N4A0 B4DMX6 B2R775 |
Accessions | CAA69875 EAW97428 Q8N4A0 AK026150 AK026438 AK312870 BAG35722 AW835269 BC036390 AAH36390 CR739813 DA109687 DQ891684 ABM82610 DQ894869 ABM85795 DQ896831 ABM87830 EU176606 ABW03407 NM_003774 NP_003765 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305|PubMed:9804815}; Single-pass type II membrane protein {ECO:0000305|PubMed:9804815}. |
Tissue Specificity | Ubiquitous. Highly expressed in mucous cells. {ECO:0000269|PubMed:9804815}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T4 CRISPR/Cas9 KO Plasmid (h) - sc-417875 from Santa Cruz Biotechnology
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GalNAc-T4 HDR Plasmid (h) - sc-417875-HDR from Santa Cruz Biotechnology
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GalNAc-T4 Double Nickase Plasmid (h) - sc-417875-NIC from Santa Cruz Biotechnology
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GalNAc-T4 Double Nickase Plasmid (h2) - sc-417875-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T4 CRISPR Activation Plasmid (h) - sc-417875-ACT from Santa Cruz Biotechnology
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GalNAc-T4 CRISPR Activation Plasmid (h2) - sc-417875-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T4 Lentiviral Activation Particles (h) - sc-417875-LAC from Santa Cruz Biotechnology
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GalNAc-T4 Lentiviral Activation Particles (h2) - sc-417875-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T4 siRNA (h) - sc-96074 from Santa Cruz Biotechnology
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GalNAc-T4 shRNA Plasmid (h) - sc-96074-SH from Santa Cruz Biotechnology
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GalNAc-T4 shRNA (h) Lentiviral Particles - sc-96074-V from Santa Cruz Biotechnology
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Polypeptide GalNac Transferase 4/GALNT4 RNAi - H00008693-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9109 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9109 from Sigma-Aldrich
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GALNT4 siRNA (Human) - CRH5721 from Cohesion Biosciences
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shRNA set against Human GALNT4 (NM_003774.4) - SHH299053 from Creative biogene
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Human GALNT4 siRNA - orb266223 from Biorbyt
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GALNT4 shRNA Plasmid (Human) - CHH5721 from Cohesion Biosciences
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GALNT4 miRNA 3'UTR clone - MiUTR4H-TG03719 from Creative biogene
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