Gene Symbol | FZD9 |
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Entrez Gene | 8326 |
Alt Symbol | CD349, FZD3 |
Species | Human |
Gene Type | protein-coding |
Description | frizzled class receptor 9 |
Other Description | frizzled 9, seven transmembrane spanning receptor|frizzled family receptor 9|frizzled homolog 9|frizzled-9|fz-9|fzE6|hFz9 |
Swissprots | O00144 |
Accessions | AAQ93359 EAW69682 O00144 BC026333 AAH26333 DQ893374 ABM84300 DQ896696 ABM87695 U82169 AAC51174 NM_003508 NP_003499 |
Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. |
Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-9 (C-14) - sc-33509 from Santa Cruz Biotechnology
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frizzled-9 (D-14) - sc-33508 from Santa Cruz Biotechnology
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frizzled-9 (E-15) - sc-33506 from Santa Cruz Biotechnology
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frizzled-9 (H-65) - sc-292864 from Santa Cruz Biotechnology
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Anti-Frizzled 9 antibody - ab61430 from Abcam
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Anti-Frizzled 9 antibody - ab195718 from Abcam
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Anti-Frizzled 9 antibody - ab61431 from Abcam
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Anti-Frizzled 9 antibody - ab83744 from Abcam
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Anti-Frizzled 9 antibody [EPR4011] - ab108628 from Abcam
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Anti-FZD9 / Frizzled 9 Antibody (aa181-230) - LS-C31305 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa144-193) - LS-C101901 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa542-591) - LS-C120600 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (Internal, clone EPR4011) - LS-C137938 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (N-Terminus) IHC-plus⢠- LS-A5118 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (N-Terminus) IHC-plus⢠- LS-A5076 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (Extracellular Domain) IHC-plus⢠- LS-A5081 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (N-Terminus) IHC-plus⢠- LS-A5103 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (N-Terminus) IHC-plus⢠- LS-A5097 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (Extracellular Domain) IHC-plus⢠- LS-A5087 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, APC) - LS-C214442 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, AP) - LS-C214441 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, Biotin) - LS-C214443 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, FITC) - LS-C214444 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, Azide-free, HRP) - LS-C214445 from LifeSpan Bioscience
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Anti-FZD9 / Frizzled 9 Antibody (aa6-35, PE) - LS-C214447 from LifeSpan Bioscience
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