FZD9
| Gene Symbol | FZD9 |
|---|---|
| Entrez Gene | 8326 |
| Alt Symbol | CD349, FZD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 9 |
| Other Description | frizzled 9, seven transmembrane spanning receptor|frizzled family receptor 9|frizzled homolog 9|frizzled-9|fz-9|fzE6|hFz9 |
| Swissprots | O00144 |
| Accessions | AAQ93359 EAW69682 O00144 BC026333 AAH26333 DQ893374 ABM84300 DQ896696 ABM87695 U82169 AAC51174 NM_003508 NP_003499 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-9 CRISPR/Cas9 KO Plasmid (h) - sc-405226 from Santa Cruz Biotechnology
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frizzled-9 HDR Plasmid (h) - sc-405226-HDR from Santa Cruz Biotechnology
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frizzled-9 Double Nickase Plasmid (h) - sc-405226-NIC from Santa Cruz Biotechnology
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frizzled-9 Double Nickase Plasmid (h2) - sc-405226-NIC-2 from Santa Cruz Biotechnology
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frizzled-9 CRISPR Activation Plasmid (h) - sc-405226-ACT from Santa Cruz Biotechnology
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frizzled-9 CRISPR Activation Plasmid (h2) - sc-405226-ACT-2 from Santa Cruz Biotechnology
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frizzled-9 Lentiviral Activation Particles (h) - sc-405226-LAC from Santa Cruz Biotechnology
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frizzled-9 Lentiviral Activation Particles (h2) - sc-405226-LAC-2 from Santa Cruz Biotechnology
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frizzled-9 siRNA (h) - sc-39994 from Santa Cruz Biotechnology
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frizzled-9 shRNA Plasmid (h) - sc-39994-SH from Santa Cruz Biotechnology
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frizzled-9 shRNA (h) Lentiviral Particles - sc-39994-V from Santa Cruz Biotechnology
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Frizzled-9 RNAi - H00008326-R02 from Novus Biologicals
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MISSION® esiRNA - EHU138811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2162 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2162 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02175 from Sigma-Aldrich
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FZD9 siRNA (Human) - CRH5448 from Cohesion Biosciences
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FZD9 - MBS8216842 from MyBioSource
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shRNA set against Human FZD9 (NM_003508.2) - SHH298157 from Creative biogene
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shRNA set against Human FZD9(NM_003508.2) - SHH072371 from Creative biogene
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Human FZD9 siRNA - orb265950 from Biorbyt
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FZD9 shRNA Plasmid (Human) - CHH5448 from Cohesion Biosciences
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FZD9 miRNA 3'UTR clone - MiUTR1H-03892 from Creative biogene
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