| Gene Symbol |
FZD9
|
| Entrez Gene |
8326
|
| Alt Symbol |
CD349, FZD3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 9
|
| Other Description |
frizzled 9, seven transmembrane spanning receptor|frizzled family receptor 9|frizzled homolog 9|frizzled-9|fz-9|fzE6|hFz9
|
| Swissprots |
O00144
|
| Accessions |
AAQ93359 EAW69682 O00144 BC026333 AAH26333 DQ893374 ABM84300 DQ896696 ABM87695 U82169 AAC51174 NM_003508 NP_003499
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|