Gene Symbol | FZD9 |
---|---|
Entrez Gene | 8326 |
Alt Symbol | CD349, FZD3 |
Species | Human |
Gene Type | protein-coding |
Description | frizzled class receptor 9 |
Other Description | frizzled 9, seven transmembrane spanning receptor|frizzled family receptor 9|frizzled homolog 9|frizzled-9|fz-9|fzE6|hFz9 |
Swissprots | O00144 |
Accessions | AAQ93359 EAW69682 O00144 BC026333 AAH26333 DQ893374 ABM84300 DQ896696 ABM87695 U82169 AAC51174 NM_003508 NP_003499 |
Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. |
Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E3186 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29029 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29031 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29032 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29030 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29036 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E29039 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E26697 from LifeSpan Bioscience
|
||||||||||
FZD9 / Frizzled 9 Antibody Blocking Peptide - LS-E15166 from LifeSpan Bioscience
|
||||||||||
FZD9-Antibody-N-term-Blocking-Peptide - BP14338a from Abgent, a WuXi AppTec company
|
||||||||||
Frizzled 9 blocking peptide - GTX88765-PEP from GeneTex
|
||||||||||
FZD9 Blocking Peptide - 33R-9266 from Fitzgerald
|
||||||||||
FZD9 Blocking Peptide - 33R-8100 from Fitzgerald
|
||||||||||
Frizzled 9 Peptide - AC21-1537-P from Abcore
|
||||||||||
Frizzled 9 Peptide - 45-637P from ProSci
|
||||||||||
FZD9 fusion protein - Ag4847 from Proteintech Group
|
||||||||||
FZD9 fusion protein - ag4971 from Proteintech Group
|
||||||||||
Recombinant Human FZD9, GST-tagged - FZD9-13071H from Creative Biomart
|
||||||||||
Frizzled 9 Blocking Peptide - CBP2272 from Cohesion Biosciences
|
||||||||||
Frizzled-9 (L591) Peptide - BS2775P from Bioworld Technology
|
||||||||||
Frizzled-9 Peptide - BS5723P from Bioworld Technology
|
||||||||||
Frizzled 9 Blocking Peptide - abx161860 from Abbexa
|
||||||||||
FZD9 Protein - abx163522 from Abbexa
|
||||||||||
FZD9, Peptide - MBS426060 from MyBioSource
|
||||||||||
FZD9 Peptide, Human - M34GP05993H from Creative Peptides
|