| Gene Symbol |
SPC25
|
| Entrez Gene |
57405
|
| Alt Symbol |
AD024, SPBC25, hSpc25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SPC25, NDC80 kinetochore complex component
|
| Other Description |
2600017H08Rik|SPC25, NDC80 kinetochore complex component, homolog|kinetochore protein Spc25|spindle pole body component 25 homolog
|
| Swissprots |
Q9HBM1 A8K4X8 D3DPC0
|
| Accessions |
AAY24098 EAX11288 EAX11289 EAX11290 Q9HBM1 AF225416 AAG09718 AK291093 BAF83782 AY456388 AAR88652 BC022255 AAH22255 CR457197 CAG33478 HQ447658 ADQ32143 XM_011511516 XP_011509818 XM_011546938 XP_011545240 XM_011546939 XP_011545241 XM_011546940 XP_011545242 NM_020675 NP_065726
|
| Function |
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
|
![Western Blot: SPC25 Overexpression Lysate (Adult Normal) [NBL1-16387] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPC25.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5496_SPC25%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16387-img0002.jpg)