| Gene Symbol |
GATM
|
| Entrez Gene |
2628
|
| Alt Symbol |
AGAT, AT, CCDS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
|
| Other Description |
glycine amidinotransferase, mitochondrial|transamidinase
|
| Swissprots |
B4DH99 Q53EQ4 B4DPI3 P50440
|
| Accessions |
EAW77306 EAW77307 EAW77308 P50440 AK098055 AK098393 AK223585 BAD97305 AK294995 BAG58060 AK298350 BAG60595 BC004141 AAH04141 BC039389 CD365153 DB048816 DB457418 S68805 AAB29892 XM_011521450 XP_011519752 XM_011521451 XP_011519753 NM_001482 NP_001473
|
| Function |
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. {ECO:0000269|PubMed:16125225, ECO:0000269|PubMed:16614068, ECO:0000269|PubMed:16820567}.
|
| Subcellular Location |
Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Probably attached to the outer side of the inner membrane.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. {ECO:0000269|PubMed:16125225, ECO:0000269|PubMed:16614068, ECO:0000269|PubMed:16820567}.
|
| Top Pathways |
Glycine, serine and threonine metabolism, Arginine and proline metabolism
|
![Western Blot: GATM Overexpression Lysate (Adult Normal) [NBL1-10988] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GATM.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2665_GATM%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10988-img0002.jpg)