Gene Symbol | GATM |
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Entrez Gene | 2628 |
Alt Symbol | AGAT, AT, CCDS3 |
Species | Human |
Gene Type | protein-coding |
Description | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
Other Description | glycine amidinotransferase, mitochondrial|transamidinase |
Swissprots | B4DH99 Q53EQ4 B4DPI3 P50440 |
Accessions | EAW77306 EAW77307 EAW77308 P50440 AK098055 AK098393 AK223585 BAD97305 AK294995 BAG58060 AK298350 BAG60595 BC004141 AAH04141 BC039389 CD365153 DB048816 DB457418 S68805 AAB29892 XM_011521450 XP_011519752 XM_011521451 XP_011519753 NM_001482 NP_001473 |
Function | Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. {ECO:0000269|PubMed:16125225, ECO:0000269|PubMed:16614068, ECO:0000269|PubMed:16820567}. |
Subcellular Location | Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Probably attached to the outer side of the inner membrane. |
Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. {ECO:0000269|PubMed:16125225, ECO:0000269|PubMed:16614068, ECO:0000269|PubMed:16820567}. |
Top Pathways | Glycine, serine and threonine metabolism, Arginine and proline metabolism |
Human GATM full length protein - ab123149 from Abcam
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Human GATM protein fragment - ab116925 from Abcam
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GATM / AGAT Antibody Blocking Peptide - LS-E215 from LifeSpan Bioscience
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GATM Partial Recombinant Protein - H00002628-Q01 from Novus Biologicals
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GATM Recombinant Protein - H00002628-P01 from Novus Biologicals
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Recombinant Human GATM Protein - NBP1-99081 from Novus Biologicals
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GATM-Antibody-N-term-Blocking-Peptide - BP10442a from Abgent, a WuXi AppTec company
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Human GATM protein - orb168381 from Biorbyt
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GATM Blocking Peptide - 33R-6995 from Fitzgerald
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Glycine amidinotransferase (38-423, His-tag) - AR50263PU-N from Acris Antibodies
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Glycine amidinotransferase (38-423, His-tag) - AR50263PU-S from Acris Antibodies
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Glycine amidinotransferase - H00002628-P01-10 from Acris Antibodies
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Glycine amidinotransferase - H00002628-P01-25 from Acris Antibodies
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Glycine amidinotransferase - H00002628-Q01-10 from Acris Antibodies
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Glycine amidinotransferase - H00002628-Q01-25 from Acris Antibodies
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GATM, 38-423aa, Human, His tag, E.coli - 01-P1438 from ARP American Research Products
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GATM fusion protein - Ag3754 from Proteintech Group
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GATM Human - ENPS-590 from NeoScientific
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Recombinant Human Glycine Amidinotransferase Enzyme - BP002794-ENZ-583 from Syd Labs
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Recombinant Human GATM protein, His-tagged - GATM-1925H from Creative Biomart
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Recombinant Human GATM - GATM-28986TH from Creative Biomart
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Recombinant Human GATM, His-tagged - GATM-13171H from Creative Biomart
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GATM Human - JNV-847 from Reagent Proteins
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GATM 38-423aa - CMB-1271 from Reagent Proteins
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Recombinant Human Glycine amidinotransferase, mitochondrial(GATM) - CSB-YP009284HU CSB-EP009284HU CSB-BP009284HU CSB-MP009284HU from Cusabio
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