| Gene Symbol |
TRPM5
|
| Entrez Gene |
29850
|
| Alt Symbol |
LTRPC5, MTR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 5
|
| Other Description |
LTrpC-5|MLSN1 and TRP-related|MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|transient receptor potential cation channel subfamily M member 5
|
| Swissprots |
Q52LU2 A6NHS0 Q9NZQ8 Q9NY34
|
| Accessions |
EAX02514 EAX02515 EAX02516 Q9NZQ8 AF177473 AAF26288 AJ270996 CAB66342 BC093787 AAH93787 BC093789 AAH93789 BC143351 AAI43352 BC143353 AAI43354 XM_011520035 XP_011518337 NM_014555 NP_055370
|
| Function |
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius
|
| Subcellular Location |
Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.
|
| Tissue Specificity |
Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed:10607831}.
|
| Top Pathways |
Taste transduction
|