TRPM5

Gene Symbol	TRPM5
Entrez Gene	29850
Alt Symbol	LTRPC5, MTR1
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily M, member 5
Other Description	LTrpC-5|MLSN1 and TRP-related|MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|transient receptor potential cation channel subfamily M member 5
Swissprots	Q52LU2 A6NHS0 Q9NZQ8 Q9NY34
Accessions	EAX02514 EAX02515 EAX02516 Q9NZQ8 AF177473 AAF26288 AJ270996 CAB66342 BC093787 AAH93787 BC093789 AAH93789 BC143351 AAI43352 BC143353 AAI43354 XM_011520035 XP_011518337 NM_014555 NP_055370
Function	Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius
Subcellular Location	Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.
Tissue Specificity	Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed:10607831}.
Top Pathways	Taste transduction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRPM5 peptide - ab123438 from Abcam Category Peptide

TRPM5 peptide - ab179838 from Abcam Category Peptide

TRPM5 Antibody Blocking Peptide - LS-E12533 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM5 Antibody Blocking Peptide - LS-E27020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM5/MTR1 blocking peptide - GTX88431-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Goat anti TRPM5 antibody Immunizing peptide - orb59533 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TRPM5 Blocking Peptide - 33R-1043 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPM5 Blocking Peptide - 33R-2505 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPM5 Peptide - AC21-1845-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPM5 Peptide - 42-147P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

TRPM5 fusion protein - Ag12593 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TRPM5 fusion protein - ag13279 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human TRPM5, GST-tagged - TRPM5-3435H from Creative Biomart Category Protein Source E.coli Species Human

TRPM5/MTR1, Peptide - MBS427012 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

TRPM5 Recombinant Protein Antigen - NBP2-48789PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TRPM5 Recombinant Protein Antigen - NBP2-48760PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TRPM5 Peptide, Human - M34GP16683H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more