TRPM5

Gene Symbol TRPM5
Entrez Gene 29850
Alt Symbol LTRPC5, MTR1
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 5
Other Description LTrpC-5|MLSN1 and TRP-related|MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|transient receptor potential cation channel subfamily M member 5
Swissprots Q52LU2 A6NHS0 Q9NZQ8 Q9NY34
Accessions EAX02514 EAX02515 EAX02516 Q9NZQ8 AF177473 AAF26288 AJ270996 CAB66342 BC093787 AAH93787 BC093789 AAH93789 BC143351 AAI43352 BC143353 AAI43354 XM_011520035 XP_011518337 NM_014555 NP_055370
Function Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius
Subcellular Location Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.
Tissue Specificity Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed:10607831}.
Top Pathways Taste transduction

TRPM5 (N-20) - sc-27366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPM5 (S-13) - sc-27367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPM5 (S-13): sc-27367. Western blot analysis of TRPM5 expression in Hep G2 whole cell lysate.

Anti-TRPM5 antibody - ab87642 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TRPM5 antibody (ab87642) at 1 µg/ml + Human Pancreas lysate at 35 µgdeveloped using the ECL technique

Anti-TRPM5 antibody - ab72151 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM5 antibody - ab72180 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM5 antibody [EPR7504] - ab154788 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7504
All lanes : Anti-TRPM5 antibody [EPR7504] (ab154788) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Human prostate lysateLane 3 : BxPC-3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-TRPM5 Antibody - LS-C95008 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM5 Antibody (Internal) - LS-C108108 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TRPM5 antibody (1 ug/ml) staining of Human Pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TRPM5 Antibody (aa247-296) - LS-C80116 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TRPM5 antibody LS-C80116 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-TRPM5 Antibody (aa205-254) IHC-plus™ - LS-B6792 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM5 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6792 concentration 5 ug/ml.

TRPM5 Antibody - NBP1-44059 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: TRPM5 Antibody [NBP1-44059] - (1ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TRPM5 Polyclonal Antibody - bs-9047R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM5 antibody produced in rabbit - HPA042115 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPM5: <B>Cat. No. HPA042115</B>: Immunohistochemical staining of human prostate shows strong granular cytoplasmic positivity in glandular cells.

Anti-TRPM5 antibody produced in rabbit - HPA043315 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPM5: <B>Cat. No. HPA043315</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity with a granular pattern in cells of tubules.

Anti-TRPM5 (AB1) antibody produced in rabbit - AV35242 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPM5 (ab1): <B>Cat. No. AV35242</B>: Immunohistochemistry of TRPM5 in Pancreas tissue with TRPM5 antibody at 4-8 μg/mL.

Anti-TRPM5 (AB2) antibody produced in rabbit - AV35243 from Sigma-Aldrich

Prices $267.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPM5 (ab2): <B>Cat. No. AV35243</B>: Immunohistochemistry of TRPM5 in Human Intestine tissue with TRPM5 antibody at 4-8 μg/mL.

TRPM5 antibody - N-terminal region (ARP35242_P050) - ARP35242_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPM5 antibody - N-terminal region (ARP35243_T100) - ARP35243_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPM5--MTR1-Antibody - AF2180a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2180a (1 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Anti-TRPM5 / MTR1 Antibody (OAEB01233) - OAEB01233 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

TRPM5 antibody - 70R-1542 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TRPM5 antibody - 70R-5146 from Fitzgerald

Prices $375.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

TRPM5 antibody - 70R-21014 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

TRPM5 antibody - AP16959PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TRPM5 antibody - 18027-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Fluorescent IHC on 1%PLP fixed frozen mouse olfactory epithelium tissue of TRPM5 antibody (18027-1-AP, 1:200). Microvillar cell staining in the apical layer. By Dr. Brian Lin (Schwob Lab).
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