TRPM5
| Gene Symbol | TRPM5 |
|---|---|
| Entrez Gene | 29850 |
| Alt Symbol | LTRPC5, MTR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily M, member 5 |
| Other Description | LTrpC-5|MLSN1 and TRP-related|MLSN1- and TRP-related gene 1 protein|long transient receptor potential channel 5|transient receptor potential cation channel subfamily M member 5 |
| Swissprots | Q52LU2 A6NHS0 Q9NZQ8 Q9NY34 |
| Accessions | EAX02514 EAX02515 EAX02516 Q9NZQ8 AF177473 AAF26288 AJ270996 CAB66342 BC093787 AAH93787 BC093789 AAH93789 BC143351 AAI43352 BC143353 AAI43354 XM_011520035 XP_011518337 NM_014555 NP_055370 |
| Function | Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius |
| Subcellular Location | Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}. |
| Tissue Specificity | Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269|PubMed:10607831}. |
| Top Pathways | Taste transduction |
TRPM5 CRISPR/Cas9 KO Plasmid (h) - sc-403223 from Santa Cruz Biotechnology
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TRPM5 HDR Plasmid (h) - sc-403223-HDR from Santa Cruz Biotechnology
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TRPM5 Double Nickase Plasmid (h) - sc-403223-NIC from Santa Cruz Biotechnology
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TRPM5 Double Nickase Plasmid (h2) - sc-403223-NIC-2 from Santa Cruz Biotechnology
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TRPM5 CRISPR Activation Plasmid (h) - sc-403223-ACT from Santa Cruz Biotechnology
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TRPM5 CRISPR Activation Plasmid (h2) - sc-403223-ACT-2 from Santa Cruz Biotechnology
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TRPM5 Lentiviral Activation Particles (h) - sc-403223-LAC from Santa Cruz Biotechnology
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TRPM5 Lentiviral Activation Particles (h2) - sc-403223-LAC-2 from Santa Cruz Biotechnology
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TRPM5 siRNA (h) - sc-44169 from Santa Cruz Biotechnology
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TRPM5 shRNA Plasmid (h) - sc-44169-SH from Santa Cruz Biotechnology
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TRPM5 shRNA (h) Lentiviral Particles - sc-44169-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU012291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22059 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22059 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03799 from Sigma-Aldrich
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TRPM5 siRNA (Human) - CRH9240 from Cohesion Biosciences
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TRPM5 RNAi - H00029850-R01 from Novus Biologicals
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TRPM5 - MBS8240636 from MyBioSource
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TRPM5 HDR Plasmid (h2) - sc-403223-HDR-2 from Santa Cruz Biotechnology
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TRPM5 CRISPR/Cas9 KO Plasmid (h2) - sc-403223-KO-2 from Santa Cruz Biotechnology
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shRNA set against Human TRPM5 (NM_014555.3) - SHH435672 from Creative biogene
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Human TRPM5 siRNA - orb269742 from Biorbyt
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TRPM5 shRNA Plasmid (Human) - CHH9240 from Cohesion Biosciences
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TRPM5 miRNA 3'UTR clone - MiUTR3H-06946 from Creative biogene
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