| Gene Symbol |
PREB
|
| Entrez Gene |
10113
|
| Alt Symbol |
SEC12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prolactin regulatory element binding
|
| Other Description |
mammalian guanine nucleotide exchange factor mSec12|prolactin regulatory binding-element protein|prolactin regulatory element-binding protein
|
| Swissprots |
Q53SZ8 Q9HCU5 Q9UH94
|
| Accessions |
AAF74572 AAX93170 EAX00626 EAX00627 EAX00628 EAX00629 EAX00630 Q9HCU5 AA629936 AF203687 AAF19192 AF226684 AAG01692 AK001976 AK023064 BAB14385 AK023405 AK292178 BAF84867 BC002765 AAH02765 BC008658 BC012890 AAH12890 BC016472 AAH16472 BC016906 AAH16906 BC036185 BC041032 AAH41032 BG715668 DQ892120 ABM83046 XM_006711914 XP_006711977 XM_011532471 XP_011530773 XM_011532472 XP_011530774 XR_939648 XR_939649 NM_013388 NP_037520
|
| Function |
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10920239, ECO:0000269|PubMed:12735795}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|