Gene Symbol | ERLIN2 |
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Entrez Gene | 11160 |
Alt Symbol | C8orf2, Erlin-2, NET32, SPFH2, SPG18 |
Species | Human |
Gene Type | protein-coding |
Description | ER lipid raft associated 2 |
Other Description | SPFH domain family, member 2|endoplasmic reticulum lipid raft-associated protein 2|erlin-2|stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 |
Swissprots | O94905 A8K5S9 D3DSW0 B4DM38 Q86VS6 Q6NW21 Q86W49 A0JLQ1 |
Accessions | BAA36845 EAW63365 EAW63366 O94905 AK057557 AK291394 BAF84083 AK297279 BAG59750 AL442077 CAC09443 AY358108 AAQ88475 AY358851 AAQ89210 BC005950 AAH05950 BC035980 BC048308 AAH48308 BC050611 AAH50611 BC067765 AAH67765 BI560439 BP353279 BP363612 BU608317 XM_005273392 XP_005273449 XM_006716280 XP_006716343 NM_001003790 NP_001003790 NM_001003791 NP_001003791 NM_007175 NP_009106 |
Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10449903}. |
Erlin-2 Antibody - 2959 from Cell Signaling Technology
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SPFH2 (C-15) - sc-82035 from Santa Cruz Biotechnology
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Anti-SPFH2 antibody - ab84691 from Abcam
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Anti-SPFH2 antibody - ab96591 from Abcam
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Anti-SPFH2 antibody - ab36123 from Abcam
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Anti-SPFH2 antibody [EPR8088] - ab129207 from Abcam
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Anti-SPFH2 antibody [EPR8089] - ab128924 from Abcam
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Anti-SPFH2 / ERLIN2 Antibody (C-Terminus) - LS-C102783 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, AP) - LS-C235048 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, APC) - LS-C246897 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (C-Terminus, clone EPR8089) - LS-C152416 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, Biotin) - LS-C246898 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333) - LS-C159563 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, FITC) - LS-C246899 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, PE) - LS-C246900 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa307-333, Azide-free, HRP) - LS-C249931 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa306-333) - LS-C321178 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa278-339) - LS-C185779 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (Internal, clone EPR8088) - LS-C152583 from LifeSpan Bioscience
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Anti-SPFH2 / ERLIN2 Antibody (aa328-339) IHC-plus⢠- LS-B9192 from LifeSpan Bioscience
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SPFH2 Antibody - NBP1-88247 from Novus Biologicals
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SPFH2 Antibody - 21320002 from Novus Biologicals
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SPFH2 Antibody - NB100-1884 from Novus Biologicals
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SPFH2 Antibody - NBP1-31479 from Novus Biologicals
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Rabbit Anti-SPFH2 Polyclonal Antibody - bs-11671R from Bioss
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