| Gene Symbol |
ERLIN2
|
| Entrez Gene |
11160
|
| Alt Symbol |
C8orf2, Erlin-2, NET32, SPFH2, SPG18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ER lipid raft associated 2
|
| Other Description |
SPFH domain family, member 2|endoplasmic reticulum lipid raft-associated protein 2|erlin-2|stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
|
| Swissprots |
O94905 A8K5S9 D3DSW0 B4DM38 Q86VS6 Q6NW21 Q86W49 A0JLQ1
|
| Accessions |
BAA36845 EAW63365 EAW63366 O94905 AK057557 AK291394 BAF84083 AK297279 BAG59750 AL442077 CAC09443 AY358108 AAQ88475 AY358851 AAQ89210 BC005950 AAH05950 BC035980 BC048308 AAH48308 BC050611 AAH50611 BC067765 AAH67765 BI560439 BP353279 BP363612 BU608317 XM_005273392 XP_005273449 XM_006716280 XP_006716343 NM_001003790 NP_001003790 NM_001003791 NP_001003791 NM_007175 NP_009106
|
| Function |
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}; Single-pass type II membrane protein {ECO:0000269|PubMed:16835267, ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10449903}.
|
![Western Blot: SPFH2 Overexpression Lysate (Adult Normal) [NBP2-10380] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPFH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2862_SPFH2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10380-img0001.jpg)