| Gene Symbol |
CBX4
|
| Entrez Gene |
8535
|
| Alt Symbol |
NBP16, PC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromobox homolog 4
|
| Other Description |
E3 SUMO-protein ligase CBX4|NS5ATP1-binding protein 16|Pc class 2 homolog|chromobox homolog 4 (Pc class homolog, Drosophila)|chromobox protein homolog 4|polycomb 2 homolog
|
| Swissprots |
Q96C04 Q6TPI8 B1PJR7 O00257
|
| Accessions |
EAW89572 EAW89573 O00257 AF013956 AAB80718 AI796748 AY390430 AAQ97596 BC014967 AAH14967 BG029608 BQ225831 EU439707 ACA49234 U94344 AAB62734 XM_011525399 XP_011523701 NM_003655 NP_003646
|
| Function |
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
|
| Subcellular Location |
Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation.
|
| Tissue Specificity |
Ubiquitous.
|