CBX4

Gene Symbol CBX4
Entrez Gene 8535
Alt Symbol NBP16, PC2
Species Human
Gene Type protein-coding
Description chromobox homolog 4
Other Description E3 SUMO-protein ligase CBX4|NS5ATP1-binding protein 16|Pc class 2 homolog|chromobox homolog 4 (Pc class homolog, Drosophila)|chromobox protein homolog 4|polycomb 2 homolog
Swissprots Q96C04 Q6TPI8 B1PJR7 O00257
Accessions EAW89572 EAW89573 O00257 AF013956 AAB80718 AI796748 AY390430 AAQ97596 BC014967 AAH14967 BG029608 BQ225831 EU439707 ACA49234 U94344 AAB62734 XM_011525399 XP_011523701 NM_003655 NP_003646
Function E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Subcellular Location Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation.
Tissue Specificity Ubiquitous.

MPc2 (T-20) - sc-19299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MPc2 (T-20): sc-19299. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

MPc2 (J-25) - sc-130822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MPc2 (J-25): sc-130822. Western blot analysis of MPc2 expression in Jurkat whole cell lysate.

Anti-CBX4 antibody - ab139815 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CBX4 in Human brain tissue with ab139815 at 20 ug/mL.

Anti-CBX4 antibody - ab186600 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CBX4 antibody - ab4189 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent imaging of human cells (U2OS) with ab4189 reveals the expected discrete nuclear structure that is termed the PcG body corresponding to the known localisation of PC2. This corresponds to results seen in Satijn et al.IF was performed with a standard paraformaldehyde technique (fixed in PBS buffered PFH 4% for 5 minutes, permeabilised with 0.5% triton-PBS for 5 minutes, blocked with 5% milk / 0.2% tween for one hour.  Primary antibody used at 1/200 in 5% milk / 0.2% TWEEN for one hour, secondary antibody for 30 minutes.  All blocking and incubation steps carried out at 37 degrees C. Nuclei counterstained with Hoechst stain (blue).

Anti-CBX4 antibody - ab114038 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab114038, at 1/250 dilution, staining CBX4 in formalin-fixed, paraffin-embedded Human Breast Carcinoma tissue by Immunohistochemistry with DAB staining.

Anti-CBX4 antibody - ab38430 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CBX4 antibody (ab38430) at 1/100 dilution + Jurkat cell lysate

Anti-CBX4 antibody - ab129807 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CBX4 antibody (ab129807) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-CBX4 antibody - ab167301 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CBX4 antibody (ab167301) at 1 µg/mlLane 1 : CBX4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-CBX4 antibody [EPR12288] - ab174300 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12288
All lanes : Anti-CBX4 antibody [EPR12288] (ab174300) at 1/10000 dilutionLane 1 : Molt4 lysateLane 2 : Jurkat lysateLane 3 : 293T lysateLane 4 : Human thymus lysateLysates/proteins at 10 µg per lane.

Anti-CBX4 Antibody (aa95-107) IHC-plus™ - LS-B128 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CBX4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B128 concentration 5 ug/ml.

Anti-HPC2 / CBX4 Antibody (aa1-228) - LS-C38293 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody - LS-C125266 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, AP) - LS-C253487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, Biotin) - LS-C253489 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, APC) - LS-C253488 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, FITC) - LS-C253490 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, Azide-free, HRP) - LS-C253491 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa410-437) - LS-C98482 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-CBX4 C-term antibody is used in Western blot to detect CBX4 in Jurkat cell lysate.

Anti-CBX4 Antibody (aa1-30, AP) - LS-C253492 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa415-444, PE) - LS-C253493 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa1-30) - LS-C168366 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CBX4 Antibody western blot of CEM cell line lysates (35 ug/lane). The CBX4 antibody detected the CBX4 protein (arrow).

Anti-CBX4 Antibody (aa1-30, APC) - LS-C253494 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa1-30, Biotin) - LS-C253495 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CBX4 Antibody (aa31-80) - LS-C201364 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Brain. CBX4 antibody dilution 1.0 ug/ml.
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