| Gene Symbol | DCLRE1B |
|---|---|
| Entrez Gene | 64858 |
| Alt Symbol | APOLLO, SNM1B, SNMIB |
| Species | Human |
| Gene Type | protein-coding |
| Description | DNA cross-link repair 1B |
| Other Description | 5' exonuclease Apollo|DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)|PSO2 homolog|SNM1 homolog B |
| Swissprots | Q9H816 Q9H9E5 |
| Accessions | AAV97812 EAW56582 EAW56583 Q9H816 AF306690 AF306691 AF306692 AF306693 AI669133 AK022872 BAB14284 AK024060 BAB14807 BC011950 BC029687 AAH29687 CR936679 DR005221 JF432466 ADZ15683 XM_005271130 XP_005271187 NM_022836 NP_073747 |
| Function | 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a |
| Subcellular Location | Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome. |