| Gene Symbol | DCLRE1B |
|---|---|
| Entrez Gene | 64858 |
| Alt Symbol | APOLLO, SNM1B, SNMIB |
| Species | Human |
| Gene Type | protein-coding |
| Description | DNA cross-link repair 1B |
| Other Description | 5' exonuclease Apollo|DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)|PSO2 homolog|SNM1 homolog B |
| Swissprots | Q9H816 Q9H9E5 |
| Accessions | AAV97812 EAW56582 EAW56583 Q9H816 AF306690 AF306691 AF306692 AF306693 AI669133 AK022872 BAB14284 AK024060 BAB14807 BC011950 BC029687 AAH29687 CR936679 DR005221 JF432466 ADZ15683 XM_005271130 XP_005271187 NM_022836 NP_073747 |
| Function | 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a |
| Subcellular Location | Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome. |
SNM1B CRISPR/Cas9 KO Plasmid (h) - sc-404905 from Santa Cruz Biotechnology
|
||||||||
SNM1B HDR Plasmid (h) - sc-404905-HDR from Santa Cruz Biotechnology
|
||||||||
SNM1B Double Nickase Plasmid (h) - sc-404905-NIC from Santa Cruz Biotechnology
|
||||||||
SNM1B Double Nickase Plasmid (h2) - sc-404905-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SNM1B CRISPR Activation Plasmid (h) - sc-404905-ACT from Santa Cruz Biotechnology
|
||||||||
SNM1B CRISPR Activation Plasmid (h2) - sc-404905-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SNM1B Lentiviral Activation Particles (h) - sc-404905-LAC from Santa Cruz Biotechnology
|
||||||||
SNM1B Lentiviral Activation Particles (h2) - sc-404905-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SNM1B siRNA (h) - sc-88509 from Santa Cruz Biotechnology
|
||||||||
SNM1B shRNA Plasmid (h) - sc-88509-SH from Santa Cruz Biotechnology
|
||||||||
SNM1B shRNA (h) Lentiviral Particles - sc-88509-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU019841 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1431 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6992 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1430 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1432 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1430 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1431 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1432 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6992 from Sigma-Aldrich
|
||||||||
DCLRE1B siRNA (Human) - CRJ2125 from Cohesion Biosciences
|
||||||||
DCLRE1B - MBS8215085 from MyBioSource
|
||||||||
shRNA set against Human DCLRE1B (NM_022836.3) - SHH275217 from Creative biogene
|
||||||||
DCLRE1B shRNA Plasmid (Human) - CHJ2125 from Cohesion Biosciences
|
||||||||
DCLRE1B miRNA 3'UTR clone - MiUTR3H-10743 from Creative biogene
|