DCLRE1B

Gene Symbol DCLRE1B
Entrez Gene 64858
Alt Symbol APOLLO, SNM1B, SNMIB
Species Human
Gene Type protein-coding
Description DNA cross-link repair 1B
Other Description 5' exonuclease Apollo|DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)|PSO2 homolog|SNM1 homolog B
Swissprots Q9H816 Q9H9E5
Accessions AAV97812 EAW56582 EAW56583 Q9H816 AF306690 AF306691 AF306692 AF306693 AI669133 AK022872 BAB14284 AK024060 BAB14807 BC011950 BC029687 AAH29687 CR936679 DR005221 JF432466 ADZ15683 XM_005271130 XP_005271187 NM_022836 NP_073747
Function 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a
Subcellular Location Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.

Human DCLRE1B full length protein - ab163897 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163897 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human DCLRE1B Protein - H00064858-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

DCLRE1B Blocking Peptide - abx063957 from Abbexa

Category Peptide
Species Human

DCLRE1B - H00064858-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

DCLRE1B fusion protein - ag3945 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

DCLRE1B Blocking Peptide - CBP2763 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human

Recombinant Human 5' exonuclease Apollo(DCLRE1B) - CSB-YP880993HU CSB-EP880993HU CSB-BP880993HU CSB-MP880993HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

SNM1B Protein - abx164880 from Abbexa

Category Protein
Species Human, Mouse, Rat

5' exonuclease Apollo (DCLRE1B), Recombinant Protein - MBS1300109 from MyBioSource

Category Protein
Prices $1,325.00, $1,325.00, $1,545.00, $1,545.00, $2,185.00, $2,185.00, $2,650.00, $2,650.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

DCLRE1B-Blocking-Peptide-Center - BP5426c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

DCLRE1B Peptide, Human - M34GP04088H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

DCLRE1B peptide - orb218626 from Biorbyt

Category Peptide
Prices $272.00, $510.00
Sizes 1 mg, 5 mg
Species Human

DCLRE1B Recombinant Protein Antigen - NBP2-57379PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Recombinant Human DCLRE1B Protein, GST-tagged - DCLRE1B-5183H from Creative Biomart

Category Protein
Source Wheat Germ
Species Human
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