ITM2C

Gene Symbol ITM2C
Entrez Gene 81618
Alt Symbol BRI3, BRICD2C, E25, E25C, ITM3
Species Human
Gene Type protein-coding
Description integral membrane protein 2C
Other Description BRICHOS domain containing 2C|cerebral protein 14|integral membrane protein 3|transmembrane protein BRI3
Swissprots Q9NQX7 Q53H84 Q8N288 Q86VK5 Q6IAE7 B3KPG4 Q4G0A8 Q9BUP8 Q8TAW0
Accessions EAW70934 EAW70935 EAW70936 EAW70937 EAW70938 Q9NQX7 AB003629 BAB46927 AF271781 AAG44792 AF272043 AAF89492 AK056321 BAG51676 AK075361 BAC11570 AK090975 BAC03562 AK126739 AK222697 BAD96417 AK295503 BAG58423 AK303199 BAG64290 AK307702 AL136603 CAB66538 AL713651 CAD28460 AY049777 AAL15434 BC002424 AAH02424 BC025742 AAH25742 BC050668 AAH50668 BC098563 AAH98563 BM842614 BX444331 CR457208 CAG33489 CR749389 D87062 BAB46918 DA138409 DA182471 EU831609 ACE87209 EU831632 ACE87232 EU831696 ACE86530 EU832488 ACE87660 EU832568 ACE86970 HQ448579 ADQ33057 NM_001012514 NP_001012532 NM_001012516 NP_001012534 NM_001287240 NP_001274169 NM_001287241 NP_001274170 NM_030926 NP_112188
Function Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.
Subcellular Location Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.
Tissue Specificity High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269|PubMed:11290423, ECO:0000269|PubMed:15606899}.

ITM2C (E-16) - sc-161747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ITM2C (E-16): sc-161747. Western blot analysis of ITM2C expression in HeLa (A) and K-562 (B) whole cell lysates and mouse liver tissue extract (C).

ITM2C (K-20) - sc-161748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ITM2C antibody - ab124481 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ITM2C antibody (ab124481) at 1/500 dilutionLane 1 : 293TLane 2 : HeLaLane 3 : Human fetal brain

Anti-ITM2C Antibody (aa27-55, AP) - LS-C260557 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55, Biotin) - LS-C260559 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55, APC) - LS-C260558 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55, FITC) - LS-C260560 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55, Azide-free, HRP) - LS-C260561 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55, PE) - LS-C260562 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa26-55) - LS-C322306 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody - LS-C308552 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ITM2C Antibody (aa101-150) - LS-C145771 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ITM2C antibody LS-C145771 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-ITM2C Antibody (aa92-227) - LS-C178890 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ITM2C Antibody (aa27-55) - LS-C159944 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ITM2C Antibody western blot of A375 cell line lysates (35 ug/lane). The ITM2C antibody detected the ITM2C protein (arrow).

ITM2C Antibody - AF4904 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of JEG‑3 human epithelial choriocarcinoma cell line and human brain tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human ITM2C Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4904) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for ITM2C at approximately 35‑36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

ITM2C Antibody - NBP2-17001 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Antibody - 31530002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELISA: ITM2C Antibody [31530002] - Affinity Purified

ITM2C Antibody - H00081618-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ITM2C Antibody [H00081618-B01P] - Analysis of ITM2C expression in transfected 293T cell line by ITM2C polyclonal antibody. Lane 1: ITM2C transfected lysate(25.41 KDa). Lane 2: Non-transfected lysate.

ITM2C Polyclonal Antibody - bs-11859R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11859R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11859R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11859R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11859R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, Cy3 Conjugated - bs-11859R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ITM2C Polyclonal Antibody, Cy5 Conjugated - bs-11859R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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