ITM2C

Gene Symbol ITM2C
Entrez Gene 81618
Alt Symbol BRI3, BRICD2C, E25, E25C, ITM3
Species Human
Gene Type protein-coding
Description integral membrane protein 2C
Other Description BRICHOS domain containing 2C|cerebral protein 14|integral membrane protein 3|transmembrane protein BRI3
Swissprots Q9NQX7 Q53H84 Q8N288 Q86VK5 Q6IAE7 B3KPG4 Q4G0A8 Q9BUP8 Q8TAW0
Accessions EAW70934 EAW70935 EAW70936 EAW70937 EAW70938 Q9NQX7 AB003629 BAB46927 AF271781 AAG44792 AF272043 AAF89492 AK056321 BAG51676 AK075361 BAC11570 AK090975 BAC03562 AK126739 AK222697 BAD96417 AK295503 BAG58423 AK303199 BAG64290 AK307702 AL136603 CAB66538 AL713651 CAD28460 AY049777 AAL15434 BC002424 AAH02424 BC025742 AAH25742 BC050668 AAH50668 BC098563 AAH98563 BM842614 BX444331 CR457208 CAG33489 CR749389 D87062 BAB46918 DA138409 DA182471 EU831609 ACE87209 EU831632 ACE87232 EU831696 ACE86530 EU832488 ACE87660 EU832568 ACE86970 HQ448579 ADQ33057 NM_001012514 NP_001012532 NM_001012516 NP_001012534 NM_001287240 NP_001274169 NM_001287241 NP_001274170 NM_030926 NP_112188
Function Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.
Subcellular Location Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.
Tissue Specificity High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269|PubMed:11290423, ECO:0000269|PubMed:15606899}.

Integral membrane protein 2C (ITM2C), Human, ELISA Kit - E01I0448 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7212564 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7207711 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7235117 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7234364 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7238994 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7243136 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7251081 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7249546 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7242156 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7210976 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7205095 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Integral membrane protein 2C (ITM2C), ELISA Kit - MBS7237613 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ITM2C ELISA Kit - E020057 from Biobool

Category ELISA Kit
Sensitivity 0.1 ng/mL.
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