ITM2C

Gene Symbol	ITM2C
Entrez Gene	81618
Alt Symbol	BRI3, BRICD2C, E25, E25C, ITM3
Species	Human
Gene Type	protein-coding
Description	integral membrane protein 2C
Other Description	BRICHOS domain containing 2C|cerebral protein 14|integral membrane protein 3|transmembrane protein BRI3
Swissprots	Q9NQX7 Q53H84 Q8N288 Q86VK5 Q6IAE7 B3KPG4 Q4G0A8 Q9BUP8 Q8TAW0
Accessions	EAW70934 EAW70935 EAW70936 EAW70937 EAW70938 Q9NQX7 AB003629 BAB46927 AF271781 AAG44792 AF272043 AAF89492 AK056321 BAG51676 AK075361 BAC11570 AK090975 BAC03562 AK126739 AK222697 BAD96417 AK295503 BAG58423 AK303199 BAG64290 AK307702 AL136603 CAB66538 AL713651 CAD28460 AY049777 AAL15434 BC002424 AAH02424 BC025742 AAH25742 BC050668 AAH50668 BC098563 AAH98563 BM842614 BX444331 CR457208 CAG33489 CR749389 D87062 BAB46918 DA138409 DA182471 EU831609 ACE87209 EU831632 ACE87232 EU831696 ACE86530 EU832488 ACE87660 EU832568 ACE86970 HQ448579 ADQ33057 NM_001012514 NP_001012532 NM_001012516 NP_001012534 NM_001287240 NP_001274169 NM_001287241 NP_001274170 NM_030926 NP_112188
Function	Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.
Subcellular Location	Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.
Tissue Specificity	High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269|PubMed:11290423, ECO:0000269|PubMed:15606899}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITM2C 293T Cell Transient Overexpression Lysate(Denatured) - H00081618-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ITM2C overexpression lysate - LY422880 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ITM2C overexpression lysate - LY422882 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ITM2C 293 Cell Lysate - 402695 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ITM2C 293 Cell Lysate - 409813 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ITM2C 293 Cell Lysate - 409814 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ITM2C Overexpression Lysate (Denatured) - H00081618-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ITM2C Overexpression Lysate (Native) - NBL1-12085 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ITM2C Overexpression Lysate (Native) - NBL1-12084 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ITM2C Overexpression Lysate (Native) - NBL1-12083 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ITM2C Over-expression Lysate Product - GWB-981629 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ITM2C Over-expression Lysate Product - GWB-5F6CE0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ITM2C Over-expression Lysate Product - GWB-43C3E3 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human ITM2C Knockdown Stable Cell Line - CSC-DC007824 from Creative biogene Category Cell Line Species Human

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