ITM2C
| Gene Symbol | ITM2C |
|---|---|
| Entrez Gene | 81618 |
| Alt Symbol | BRI3, BRICD2C, E25, E25C, ITM3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integral membrane protein 2C |
| Other Description | BRICHOS domain containing 2C|cerebral protein 14|integral membrane protein 3|transmembrane protein BRI3 |
| Swissprots | Q9NQX7 Q53H84 Q8N288 Q86VK5 Q6IAE7 B3KPG4 Q4G0A8 Q9BUP8 Q8TAW0 |
| Accessions | EAW70934 EAW70935 EAW70936 EAW70937 EAW70938 Q9NQX7 AB003629 BAB46927 AF271781 AAG44792 AF272043 AAF89492 AK056321 BAG51676 AK075361 BAC11570 AK090975 BAC03562 AK126739 AK222697 BAD96417 AK295503 BAG58423 AK303199 BAG64290 AK307702 AL136603 CAB66538 AL713651 CAD28460 AY049777 AAL15434 BC002424 AAH02424 BC025742 AAH25742 BC050668 AAH50668 BC098563 AAH98563 BM842614 BX444331 CR457208 CAG33489 CR749389 D87062 BAB46918 DA138409 DA182471 EU831609 ACE87209 EU831632 ACE87232 EU831696 ACE86530 EU832488 ACE87660 EU832568 ACE86970 HQ448579 ADQ33057 NM_001012514 NP_001012532 NM_001012516 NP_001012534 NM_001287240 NP_001274169 NM_001287241 NP_001274170 NM_030926 NP_112188 |
| Function | Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}. |
| Subcellular Location | Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}. |
| Tissue Specificity | High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269|PubMed:11290423, ECO:0000269|PubMed:15606899}. |
ITM2C CRISPR/Cas9 KO Plasmid (h) - sc-409337 from Santa Cruz Biotechnology
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ITM2C HDR Plasmid (h) - sc-409337-HDR from Santa Cruz Biotechnology
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ITM2C Double Nickase Plasmid (h) - sc-409337-NIC from Santa Cruz Biotechnology
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ITM2C Double Nickase Plasmid (h2) - sc-409337-NIC-2 from Santa Cruz Biotechnology
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ITM2C CRISPR Activation Plasmid (h) - sc-409337-ACT from Santa Cruz Biotechnology
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ITM2C CRISPR Activation Plasmid (h2) - sc-409337-ACT-2 from Santa Cruz Biotechnology
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ITM2C Lentiviral Activation Particles (h) - sc-409337-LAC from Santa Cruz Biotechnology
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ITM2C Lentiviral Activation Particles (h2) - sc-409337-LAC-2 from Santa Cruz Biotechnology
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ITM2C siRNA (h) - sc-94875 from Santa Cruz Biotechnology
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ITM2C shRNA Plasmid (h) - sc-94875-SH from Santa Cruz Biotechnology
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ITM2C shRNA (h) Lentiviral Particles - sc-94875-V from Santa Cruz Biotechnology
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ITM2C RNAi - H00081618-R01 from Novus Biologicals
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ITM2C RNAi - H00081618-R03 from Novus Biologicals
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ITM2C RNAi - H00081618-R02 from Novus Biologicals
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MISSION® esiRNA - EHU070201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10831 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08177 from Sigma-Aldrich
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ITM2C siRNA (Human) - CRJ3026 from Cohesion Biosciences
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ITM2C, siRNA - MBS8212651 from MyBioSource
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shRNA set against Human ITM2C (NM_030926.4) - SHH321601 from Creative biogene
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shRNA set against Human ITM2C(NM_030926.4) - SHG105031 from Creative biogene
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shRNA set against Human ITM2C(NM_001012516.1) - SHG105085 from Creative biogene
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shRNA set against Human ITM2C(NM_001012514.1) - SHG105139 from Creative biogene
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ITM2C shRNA Plasmid (Human) - CHJ3026 from Cohesion Biosciences
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