| Gene Symbol |
MIB1
|
| Entrez Gene |
57534
|
| Alt Symbol |
DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mindbomb E3 ubiquitin protein ligase 1
|
| Other Description |
DAPK-interacting protein 1|E3 ubiquitin-protein ligase MIB1|ubiquitin ligase mind bomb|zinc finger ZZ type with ankyrin repeat domain protein 2
|
| Swissprots |
Q6YI51 Q86YT6 Q8TCB5 Q2TB37 B0YJ38 Q8NBY0 Q8TCL7 Q68D01 Q9P2M3
|
| Accessions |
ACA06016 CCQ43646 EAX01132 Q86YT6 AB037744 BAA92561 AK027338 AK075157 BAC11439 AK091266 BAG52320 AL713705 CAD28502 AY147849 AAN18023 AY149908 AAN75493 BC022403 AAH22403 BC110581 AAI10582 BC110582 AAI10583 CR749635 CAH18429 HQ234313 XM_011526098 XP_011524400 XR_935234 XR_935235 NM_020774 NP_065825
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269|PubMed:10718198}.
|