MIB1

Gene Symbol	MIB1
Entrez Gene	57534
Alt Symbol	DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
Species	Human
Gene Type	protein-coding
Description	mindbomb E3 ubiquitin protein ligase 1
Other Description	DAPK-interacting protein 1|E3 ubiquitin-protein ligase MIB1|ubiquitin ligase mind bomb|zinc finger ZZ type with ankyrin repeat domain protein 2
Swissprots	Q6YI51 Q86YT6 Q8TCB5 Q2TB37 B0YJ38 Q8NBY0 Q8TCL7 Q68D01 Q9P2M3
Accessions	ACA06016 CCQ43646 EAX01132 Q86YT6 AB037744 BAA92561 AK027338 AK075157 BAC11439 AK091266 BAG52320 AL713705 CAD28502 AY147849 AAN18023 AY149908 AAN75493 BC022403 AAH22403 BC110581 AAI10582 BC110582 AAI10583 CR749635 CAH18429 HQ234313 XM_011526098 XP_011524400 XR_935234 XR_935235 NM_020774 NP_065825
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.
Tissue Specificity	Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269|PubMed:10718198}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mib1/Mindbomb protein fragment - ab153455 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Mind Bomb 1/MIB1 Protein - H00057534-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Mind Bomb 1/MIB1 Peptide - P0990 from Novus Biologicals Category Peptide Species Human

Mib1Mindbomb-Antibody-N-term-Blocking-peptide - BP2172a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human DIP1 protein - orb245555 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Mindbomb Homolog 1 Protein - abx068021 from Abbexa Category Protein Source E.coli Species Human

MIB1 - H00057534-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MIB1 - H00057534-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Mindbomb Homolog 1 (MIB1), Human - 20-9481 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

MIB1 Peptide - 7781P from ProSci Category Peptide Species Human

MIB1 fusion protein - Ag2507 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MIB1, GST-tagged - MIB1-870H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Mindbomb Homolog 1 (MIB1) - RPL727Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mindbomb Homolog 1 (MIB1) - RPL727Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human E3 ubiquitin-protein ligase MIB1 protein - CSB-EP132874h CSB-BP132874h CSB-MP132874h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human E3 ubiquitin-protein ligase MIB1(MIB1) ,partial - CSB-YP771476HU CSB-EP771476HU CSB-BP771476HU CSB-MP771476HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human E3 ubiquitin-protein ligase MIB1(MIB1) ,partial - CSB-RP132874h from Cusabio Category Protein Source E.coli Species Human

MIB1 - TP321377 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Mind Bomb 1/MIB1 Recombinant Protein Antigen - NBP1-85210PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mib1Mindbomb-Antibody-C-term-Blocking-peptide - BP2172b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Mib1Mindbomb-Antibody-Center-Blocking-peptide - BP2172c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MIB1 Peptide, Human - M34GP09502H from Creative Peptides Category Peptide Source Synthetic. Species Human

MIB1 Blocking Peptide - CBP7465 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

MIB1 Recombinant Protein (OPCD05262) - OPCD05262 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant human E3 ubiquitin-protein ligase MIB1 - AP72212 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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