MIB1
| Gene Symbol | MIB1 |
|---|---|
| Entrez Gene | 57534 |
| Alt Symbol | DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mindbomb E3 ubiquitin protein ligase 1 |
| Other Description | DAPK-interacting protein 1|E3 ubiquitin-protein ligase MIB1|ubiquitin ligase mind bomb|zinc finger ZZ type with ankyrin repeat domain protein 2 |
| Swissprots | Q6YI51 Q86YT6 Q8TCB5 Q2TB37 B0YJ38 Q8NBY0 Q8TCL7 Q68D01 Q9P2M3 |
| Accessions | ACA06016 CCQ43646 EAX01132 Q86YT6 AB037744 BAA92561 AK027338 AK075157 BAC11439 AK091266 BAG52320 AL713705 CAD28502 AY147849 AAN18023 AY149908 AAN75493 BC022403 AAH22403 BC110581 AAI10582 BC110582 AAI10583 CR749635 CAH18429 HQ234313 XM_011526098 XP_011524400 XR_935234 XR_935235 NM_020774 NP_065825 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}. |
| Tissue Specificity | Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269|PubMed:10718198}. |
MIB1 CRISPR/Cas9 KO Plasmid (h) - sc-404769 from Santa Cruz Biotechnology
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MIB1 HDR Plasmid (h) - sc-404769-HDR from Santa Cruz Biotechnology
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MIB1 Double Nickase Plasmid (h) - sc-404769-NIC from Santa Cruz Biotechnology
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MIB1 Double Nickase Plasmid (h2) - sc-404769-NIC-2 from Santa Cruz Biotechnology
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MIB1 CRISPR Activation Plasmid (h) - sc-404769-ACT from Santa Cruz Biotechnology
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MIB1 CRISPR Activation Plasmid (h2) - sc-404769-ACT-2 from Santa Cruz Biotechnology
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MIB1 Lentiviral Activation Particles (h) - sc-404769-LAC from Santa Cruz Biotechnology
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MIB1 Lentiviral Activation Particles (h2) - sc-404769-LAC-2 from Santa Cruz Biotechnology
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MIB1 siRNA (h) - sc-75781 from Santa Cruz Biotechnology
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MIB1 shRNA Plasmid (h) - sc-75781-SH from Santa Cruz Biotechnology
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MIB1 shRNA (h) Lentiviral Particles - sc-75781-V from Santa Cruz Biotechnology
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Mind Bomb 1/MIB1 RNAi - H00057534-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13313 from Sigma-Aldrich
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MIB1 siRNA (Human) - CRJ1515 from Cohesion Biosciences
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shRNA set against Human MIB1 (NM_020774.2) - SHH341795 from Creative biogene
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shRNA set against Human MIB1(NM_020774.2) - SHH189227 from Creative biogene
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Human MIB1 siRNA - orb272016 from Biorbyt
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MIB1 shRNA Plasmid (Human) - CHJ1515 from Cohesion Biosciences
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MIB1 miRNA 3'UTR clone - MiUTR1H-06296 from Creative biogene
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