MIB1

Gene Symbol	MIB1
Entrez Gene	57534
Alt Symbol	DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
Species	Human
Gene Type	protein-coding
Description	mindbomb E3 ubiquitin protein ligase 1
Other Description	DAPK-interacting protein 1|E3 ubiquitin-protein ligase MIB1|ubiquitin ligase mind bomb|zinc finger ZZ type with ankyrin repeat domain protein 2
Swissprots	Q6YI51 Q86YT6 Q8TCB5 Q2TB37 B0YJ38 Q8NBY0 Q8TCL7 Q68D01 Q9P2M3
Accessions	ACA06016 CCQ43646 EAX01132 Q86YT6 AB037744 BAA92561 AK027338 AK075157 BAC11439 AK091266 BAG52320 AL713705 CAD28502 AY147849 AAN18023 AY149908 AAN75493 BC022403 AAH22403 BC110581 AAI10582 BC110582 AAI10583 CR749635 CAH18429 HQ234313 XM_011526098 XP_011524400 XR_935234 XR_935235 NM_020774 NP_065825
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.
Tissue Specificity	Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269|PubMed:10718198}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MIB1 Antibody - 4400 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

MIB1 (B-9) - sc-393811 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MIB1 (D-6) - sc-393551 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MIB1 (D-19) - sc-85059 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MIB1 (H-211) - sc-368128 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MIB1 (K-19) - sc-85060 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MIB1 (N-20) - sc-85061 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Mib1/Mindbomb antibody [EPR2762(2)] - ab124929 from Abcam Prices $394.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2762(2)

Anti-Mib1/Mindbomb antibody - C-terminal - ab191839 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mib1/Mindbomb antibody - N-terminal - ab71749 from Abcam Prices $385.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Mib1/Mindbomb antibody - N-terminal - ab189552 from Abcam Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (N-Terminus) - LS-C130744 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (aa365-461) - LS-C182913 from LifeSpan Bioscience Prices $650.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-MIB1 Antibody (N-Terminus) - LS-C210143 from LifeSpan Bioscience Prices $405.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (C-Terminus, APC) - LS-C225898 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (C-Terminus, AP) - LS-C225897 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (C-Terminus, Biotin) - LS-C225899 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (C-Terminus, FITC) - LS-C225900 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (aa15-45, AP) - LS-C225901 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (C-Terminus, Azide-free, HRP) - LS-C225902 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody - LS-C211423 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (HRP) - LS-C211424 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (clone 3E10) - LS-C139207 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E10

Anti-MIB1 Antibody (FITC) - LS-C211425 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MIB1 Antibody (aa15-45, APC) - LS-C225903 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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