PRKAA1

Gene Symbol	PRKAA1
Entrez Gene	5562
Alt Symbol	AMPK, AMPKa1
Species	Human
Gene Type	protein-coding
Description	protein kinase, AMP-activated, alpha 1 catalytic subunit
Other Description	5'-AMP-activated protein kinase catalytic subunit alpha-1|5'-AMP-activated protein kinase, catalytic alpha-1 chain|ACACA kinase|AMP -activate kinase alpha 1 subunit|AMP-activated protein kinase, catalytic, alpha-1|AMPK alpha 1|AMPK subunit alpha-1|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase|tau-protein kinase PRKAA1
Swissprots	Q86VS1 Q5D0E1 O00286 Q9UNQ4 A8MTQ6 Q13131 B2R7E1
Accessions	EAW56000 EAW56001 Q13131 AB022017 BAA36547 AF100763 AAD43027 AK024252 AK307546 AK312947 BAG35788 BC012622 AAH12622 BC037303 AAH37303 BC048980 AAH48980 BQ049192 BQ716041 BX494823 CD512588 DB236105 JF432366 ADZ15583 U22456 AAA64850 Y12856 CAA73361 XM_006714482 XP_006714545 NM_006251 NP_006242 NM_206907 NP_996790
Function	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15866171}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Top Pathways	Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AMPK alpha 1 + AMPK beta 2 + AMPK gamma 3 full length protein - ab184885 from Abcam Category Protein Prices $697.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human AMPK alpha 1 + AMPK beta 2 +AMPK gamma 2 full length protein - ab184883 from Abcam Category Protein Prices $697.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human AMPK alpha1 + AMPK beta1 + AMPK gamma1 full length protein - ab79803 from Abcam Category Protein Prices $465.00, $939.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human AMPK alpha 1 peptide - ab40461 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human AMPK alpha 1 protein fragment - ab132944 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AMPK alpha 1 protein fragment - ab159185 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AMPK alpha 1 protein fragment - ab159187 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AMPK alpha 1 protein fragment - ab202156 from Abcam Category Protein Prices $429.00 Sizes 100 µg Source E. coli Species Human

PRKAA1 / AMPK Alpha 1 Antibody Blocking Peptide - LS-E19395 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA1 / AMPK Alpha 1 Antibody Blocking Peptide - LS-E19394 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA1 / AMPK Alpha 1 Antibody Blocking Peptide - LS-E19510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA1 / AMPK Alpha 1 Antibody Blocking Peptide - LS-E8809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAA1 / AMPK Alpha 1 Antibody Blocking Peptide - LS-E8761 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AMPK alpha 1 Partial Recombinant Protein - H00005562-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AMPK alpha 1 Recombinant Protein - H00005562-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

AMPK alpha 1 Recombinant Protein - P4649 from Novus Biologicals Category Protein Prices $1,599.00 Sizes 100 µg Species Human

AMPK alpha 1 Peptide - P2370 from Novus Biologicals Category Peptide Species Human

AMPK alpha 1 Peptide - P2438 from Novus Biologicals Category Peptide Species Human

AMPK-alpha-PRKAA1-Antibody-S487-Blocking-peptide - BP7260a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AMPK-alpha-1-Antibody-C-term-Blocking-Peptide - BP7201a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AAPK1 peptide - orb217788 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

AMPKa1 Blocking Peptide - 33R-11023 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PRKAA1 Blocking Peptide - 33R-3235 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKAA1 Blocking Peptide - 33R-8915 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AMPK alpha 1 (phospho-Ser496) Blocking Peptide - abx062187 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

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