PRKAA1
| Gene Symbol | PRKAA1 |
|---|---|
| Entrez Gene | 5562 |
| Alt Symbol | AMPK, AMPKa1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, AMP-activated, alpha 1 catalytic subunit |
| Other Description | 5'-AMP-activated protein kinase catalytic subunit alpha-1|5'-AMP-activated protein kinase, catalytic alpha-1 chain|ACACA kinase|AMP -activate kinase alpha 1 subunit|AMP-activated protein kinase, catalytic, alpha-1|AMPK alpha 1|AMPK subunit alpha-1|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase|tau-protein kinase PRKAA1 |
| Swissprots | Q86VS1 Q5D0E1 O00286 Q9UNQ4 A8MTQ6 Q13131 B2R7E1 |
| Accessions | EAW56000 EAW56001 Q13131 AB022017 BAA36547 AF100763 AAD43027 AK024252 AK307546 AK312947 BAG35788 BC012622 AAH12622 BC037303 AAH37303 BC048980 AAH48980 BQ049192 BQ716041 BX494823 CD512588 DB236105 JF432366 ADZ15583 U22456 AAA64850 Y12856 CAA73361 XM_006714482 XP_006714545 NM_006251 NP_006242 NM_206907 NP_996790 |
| Function | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15866171}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. |
| Top Pathways | Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway |
AMPKα1 CRISPR/Cas9 KO Plasmid (h) - sc-400104 from Santa Cruz Biotechnology
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AMPKα1 HDR Plasmid (h) - sc-400104-HDR from Santa Cruz Biotechnology
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AMPKα1 Double Nickase Plasmid (h) - sc-400104-NIC from Santa Cruz Biotechnology
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AMPKα1 Double Nickase Plasmid (h2) - sc-400104-NIC-2 from Santa Cruz Biotechnology
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AMPKα1 CRISPR Activation Plasmid (h) - sc-400104-ACT from Santa Cruz Biotechnology
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AMPKα1 CRISPR Activation Plasmid (h2) - sc-400104-ACT-2 from Santa Cruz Biotechnology
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AMPKα1 Lentiviral Activation Particles (h) - sc-400104-LAC from Santa Cruz Biotechnology
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AMPKα1 Lentiviral Activation Particles (h2) - sc-400104-LAC-2 from Santa Cruz Biotechnology
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AMPKα1 siRNA (h) - sc-29673 from Santa Cruz Biotechnology
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AMPKα1 shRNA Plasmid (h) - sc-29673-SH from Santa Cruz Biotechnology
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AMPKα1 shRNA (h) Lentiviral Particles - sc-29673-V from Santa Cruz Biotechnology
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AMPKα1 siRNA (h2) - sc-44281 from Santa Cruz Biotechnology
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AMPKα1 shRNA Plasmid (h2) - sc-44281-SH from Santa Cruz Biotechnology
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AMPKα1 shRNA (h2) Lentiviral Particles - sc-44281-V from Santa Cruz Biotechnology
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AMPKα1/2 siRNA (h) - sc-45312 from Santa Cruz Biotechnology
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AMPKå1/2 shRNA Plasmid (h) - sc-45312-SH from Santa Cruz Biotechnology
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AMPKå1/2 shRNA (h) Lentiviral Particles - sc-45312-V from Santa Cruz Biotechnology
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AMPK alpha 1 RNAi - H00005562-R03 from Novus Biologicals
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AMPK alpha 1 RNAi - H00005562-R04 from Novus Biologicals
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MISSION® esiRNA - EHU074041 from Sigma-Aldrich
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MISSION® siRNA - SIHK1778 from Sigma-Aldrich
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MISSION® siRNA - SIHK1777 from Sigma-Aldrich
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MISSION® siRNA - SIHK1776 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1054 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1054 from Sigma-Aldrich
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