| Gene Symbol |
SEMA4C
|
| Entrez Gene |
54910
|
| Alt Symbol |
M-SEMA-F, SEMACL1, SEMAF, SEMAI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
|
| Other Description |
M-Sema F|semaphorin-4C
|
| Swissprots |
Q32MJ3 Q9C0C4 Q7Z5X0
|
| Accessions |
AAY14967 EAW71325 EAW71326 EAW71327 Q9C0C4 AB051526 BAB21830 AF258577 AAG23780 AF370374 AAQ15210 AK000376 BAA91124 AK075388 BAC11588 AK126512 BAG54340 AY358842 AAQ89201 BC017476 AAH17476 BC062984 AAH62984 BC109103 AAI09104 BC109104 AAI09105 BI518922 XM_006712606 XP_006712669 XM_011511378 XP_011509680 XM_011511379 XP_011509681 XM_011511380 XP_011509682 XM_011511381 XP_011509683 XM_011511382 XP_011509684 XM_011511383 XP_011509685 NM_017789 NP_060259
|
| Function |
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: SEMA4C Overexpression Lysate (Adult Normal) [NBL1-15802] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SEMA4C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4071_SEMA4C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15802-img0002.jpg)