Gene Symbol | SEMA4C |
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Entrez Gene | 54910 |
Alt Symbol | M-SEMA-F, SEMACL1, SEMAF, SEMAI |
Species | Human |
Gene Type | protein-coding |
Description | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C |
Other Description | M-Sema F|semaphorin-4C |
Swissprots | Q32MJ3 Q9C0C4 Q7Z5X0 |
Accessions | AAY14967 EAW71325 EAW71326 EAW71327 Q9C0C4 AB051526 BAB21830 AF258577 AAG23780 AF370374 AAQ15210 AK000376 BAA91124 AK075388 BAC11588 AK126512 BAG54340 AY358842 AAQ89201 BC017476 AAH17476 BC062984 AAH62984 BC109103 AAI09104 BC109104 AAI09105 BI518922 XM_006712606 XP_006712669 XM_011511378 XP_011509680 XM_011511379 XP_011509681 XM_011511380 XP_011509682 XM_011511381 XP_011509683 XM_011511382 XP_011509684 XM_011511383 XP_011509685 NM_017789 NP_060259 |
Function | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Top Pathways | Axon guidance |
Human SEMA4C protein fragment - ab162889 from Abcam
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Human SEMA4C protein fragment - ab191928 from Abcam
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SEMA4C / Semaphorin 4C Antibody Blocking Peptide - LS-E2106 from LifeSpan Bioscience
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Semaphorin 4C Partial Recombinant Protein - H00054910-Q01 from Novus Biologicals
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SEMA4C-Antibody-C-term-Blocking-peptide - BP13003b from Abgent, a WuXi AppTec company
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Recombinant Human Semaphorin 4C Fc Chimera, CF - 6125-S4-050 from R&D Systems
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Human SEMA4C protein - orb180408 from Biorbyt
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SEMA4C - H00054910-Q01-10 from Acris Antibodies
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SEMA4C - H00054910-Q01-25 from Acris Antibodies
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Recombinant Human Semaphorin-4C(SEMA4C) - CSB-YP863177HU CSB-EP863177HU CSB-BP863177HU CSB-MP863177HU from Cusabio
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Recombinant Human Semaphorin 4C Fc Chimera Protein, CF - 6125-S4 from R&D Systems
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SEMA4C Protein - abx163301 from Abbexa
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Semaphorin 4C Recombinant Protein Antigen - NBP1-80769PEP from Novus Biologicals
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SEMA4C Peptide, Human - M34GP13986H from Creative Peptides
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Semaphorin-4C (SEMA4C), Recombinant Protein - MBS1394633 from MyBioSource
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Recombinant Mouse Semaphorin 4C Fc Chimera Protein, CF - 8394-S4 from Novus Biologicals
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