Gene Symbol | SEMA4C |
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Entrez Gene | 54910 |
Alt Symbol | M-SEMA-F, SEMACL1, SEMAF, SEMAI |
Species | Human |
Gene Type | protein-coding |
Description | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C |
Other Description | M-Sema F|semaphorin-4C |
Swissprots | Q32MJ3 Q9C0C4 Q7Z5X0 |
Accessions | AAY14967 EAW71325 EAW71326 EAW71327 Q9C0C4 AB051526 BAB21830 AF258577 AAG23780 AF370374 AAQ15210 AK000376 BAA91124 AK075388 BAC11588 AK126512 BAG54340 AY358842 AAQ89201 BC017476 AAH17476 BC062984 AAH62984 BC109103 AAI09104 BC109104 AAI09105 BI518922 XM_006712606 XP_006712669 XM_011511378 XP_011509680 XM_011511379 XP_011509681 XM_011511380 XP_011509682 XM_011511381 XP_011509683 XM_011511382 XP_011509684 XM_011511383 XP_011509685 NM_017789 NP_060259 |
Function | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Top Pathways | Axon guidance |
SEMA4C CRISPR/Cas9 KO Plasmid (h) - sc-409977 from Santa Cruz Biotechnology
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SEMA4C HDR Plasmid (h) - sc-409977-HDR from Santa Cruz Biotechnology
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SEMA4C Double Nickase Plasmid (h) - sc-409977-NIC from Santa Cruz Biotechnology
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SEMA4C Double Nickase Plasmid (h2) - sc-409977-NIC-2 from Santa Cruz Biotechnology
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SEMA4C CRISPR Activation Plasmid (h) - sc-409977-ACT from Santa Cruz Biotechnology
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SEMA4C CRISPR Activation Plasmid (h2) - sc-409977-ACT-2 from Santa Cruz Biotechnology
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SEMA4C Lentiviral Activation Particles (h) - sc-409977-LAC from Santa Cruz Biotechnology
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SEMA4C Lentiviral Activation Particles (h2) - sc-409977-LAC-2 from Santa Cruz Biotechnology
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SEMA4C siRNA (h) - sc-94903 from Santa Cruz Biotechnology
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SEMA4C shRNA Plasmid (h) - sc-94903-SH from Santa Cruz Biotechnology
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SEMA4C shRNA (h) Lentiviral Particles - sc-94903-V from Santa Cruz Biotechnology
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Semaphorin 4C RNAi - H00054910-R02 from Novus Biologicals
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MISSION® esiRNA - EHU028721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19072 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19072 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07097 from Sigma-Aldrich
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SEMA4C siRNA (Human) - CRJ0317 from Cohesion Biosciences
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SEMA4C - MBS8216610 from MyBioSource
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shRNA set against Human SEMA4C (NM_017789.4) - SHH404292 from Creative biogene
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Human SEMA4C siRNA - orb270818 from Biorbyt
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SEMA4C shRNA Plasmid (Human) - CHJ0317 from Cohesion Biosciences
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SEMA4C miRNA 3'UTR clone - MiUTR1H-09254 from Creative biogene
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