LRP4

Gene Symbol	LRP4
Entrez Gene	4038
Alt Symbol	CLSS, LRP-4, LRP10, MEGF7, SOST2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 4
Other Description	low-density lipoprotein receptor-related protein 4|multiple epidermal growth factor-like domains 7
Swissprots	B2RN39 O75096 Q5KTZ5 Q4AC85
Accessions	EAW67974 EAW67975 O75096 AB011540 BAA32468 AB084910 BAD83615 AB231861 BAE19679 AK027175 BC037360 AAH37360 BC041048 AAH41048 BC136667 AAI36668 BC136668 AAI36669 BQ446811 DA799511 DB061460 XM_011520102 XP_011518404 XM_011520103 XP_011518405 XM_011520104 XP_011518406 NM_002334 NP_002325
Function	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. {ECO:0000269|PubMed:20381006, ECO:000026
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. {ECO:0000269|PubMed:21471202}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LRP4 (H-98) - sc-98775 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-LRP4 antibody [MM0803-40J26] - ab201923 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0803-40J26

Anti-LRP4 Antibody (Cytoplasmic Domain) - LS-C130475 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (aa1747-1905, clone S164-6) - LS-C209509 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (C-Terminus, Biotin) - LS-C219927 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (C-Terminus, AP) - LS-C219926 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (C-Terminus, APC) - LS-C219928 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (C-Terminus, FITC) - LS-C219929 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (C-Terminus, PE) - LS-C219931 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 390) - LS-C228745 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (C-Terminus, Azide-free, HRP) - LS-C219930 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 488) - LS-C228747 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 594) - LS-C228748 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 633) - LS-C228751 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 565) - LS-C228750 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 655) - LS-C228749 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 700) - LS-C228753 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Atto 680) - LS-C228752 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, APC) - LS-C228755 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, AP) - LS-C228754 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, Biotin) - LS-C228756 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa1747-1905, clone S164-6, FITC) - LS-C228757 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S164-6

Anti-LRP4 Antibody (aa26-350, clone S207-27, Atto 390) - LS-C228781 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S207-27

Anti-LRP4 Antibody (aa26-350, clone S207-27, Atto 488) - LS-C228782 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S207-27

Anti-LRP4 Antibody (aa26-350, clone S207-27) - LS-C209514 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S207-27

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